Prince Louis Maria of Bourbon-Two Sicilies, Count of Trani (1 August 1838, Naples – 8 June 1886, Paris) was the eldest son of Ferdinand II of the Two Sicilies and his second wife Archduchess Maria Theresa of Austria.

His maternal grandparents were Archduke Charles, Duke of Teschen and Princess Henrietta of Nassau-Weilburg, Duchess of Teschen. The Duke of Teschen was a son of Leopold II, Holy Roman Emperor. The Duchess of Teschen was a great-granddaughter of Anne, Princess Royal and Princess of Orange, herself a daughter of George II of the United Kingdom.

Louis was a younger half-brother of Francis II of the Two Sicilies. He was second-in-line to the throne of the Two Sicilies since the time of his birth.

Their father died on 22 May 1859. Francis became King but had no children yet from his wife Maria Sophie of Bavaria. Louis became his heir presumptive. However the Two Sicilies were conquered by the Expedition of the Thousand under Giuseppe Garibaldi in 1861. Garibaldi served the Kingdom of Sardinia which was in the process of Italian unification.

Louis was still the heir of Francis as head of a deposed Royal House. He retained this position for the rest of his life but predeceased Francis. Francis was eventually succeeded by their younger brother Prince Alfonso, Count of Caserta.

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