Poyle is a largely industrial and agricultural area in the unitary authority of Slough, in the ceremonial county of Berkshire, England. It is located 18 miles (29 km) west of Charing Cross in London and immediately west of the M25 motorway, near Heathrow Airport; it also adjoins the Colne Valley regional park.
Historically in Middlesex, Poyle was transferred to Surrey in 1965 and to Berkshire in 1995. Together with the neighbouring village of Colnbrook to the west, it forms the Colnbrook with Poyle civil parish.
Poyle lay within Middlesex since before the Norman Conquest as part of Stanwell, developing a manor in the early Middle Ages. In 1894 it became part of Staines Urban District, which transferred to Surrey in 1965 following the dissolution of Middlesex. In 1974, Staines Urban District was absorbed into the new borough of Spelthorne under the Local Government Act 1972; the construction of the M25 in the 1980s separated Poyle from the other settlements in the borough. In 1995, it and the neighbouring village of Colnbrook (in Buckinghamshire) were transferred to Berkshire, forming the new Colnbrook with Poyle parish of the borough of Slough.