Plakoglobin

JUP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IFQ
Identifiers
Aliases	JUP, ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB, Plakoglobin, junction plakoglobin
External IDs	MGI: 96650 HomoloGene: 1680 GeneCards: JUP
Gene ontology Molecular function • protein homodimerization activity • transcription coactivator activity • structural constituent of cell wall • structural molecule activity • signal transducer activity • protein binding • cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication • protein phosphatase binding • protein kinase binding • alpha-catenin binding • cell adhesion molecule binding • cadherin binding Cellular component • cytoplasm • cytosol • gamma-catenin-TCF7L2 complex • lateral plasma membrane • membrane • intercalated disc • cell-cell junction • focal adhesion • adherens junction • plasma membrane • desmosome • hemidesmosome • cell-cell adherens junction • cell junction • apicolateral plasma membrane • protein-DNA complex • Z disc • actin cytoskeleton • zonula adherens • cytoplasmic side of plasma membrane • catenin complex • fascia adherens • cytoskeleton • intermediate filament • extracellular exosome • nucleus • extracellular matrix • cornified envelope • extracellular region • specific granule lumen • ficolin-1-rich granule lumen Biological process • single organismal cell-cell adhesion • adherens junction assembly • protein heterooligomerization • positive regulation of canonical Wnt signaling pathway • positive regulation of sequence-specific DNA binding transcription factor activity • bundle of His cell-Purkinje myocyte adhesion involved in cell communication • endothelial cell-cell adhesion • cellular response to indole-3-methanol • desmosome assembly • cell adhesion • cytoskeletal anchoring at plasma membrane • regulation of cell proliferation • detection of mechanical stimulus • positive regulation of protein import into nucleus • adherens junction organization • regulation of heart rate by cardiac conduction • cell migration • regulation of ventricular cardiac muscle cell action potential • skin development • establishment of protein localization to plasma membrane • signal transduction • keratinization • neutrophil degranulation • cornification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3728	16480
Ensembl	ENSG00000173801	ENSMUSG00000001552
UniProt	P14923	Q02257
RefSeq (mRNA)	NM_002230 NM_021991	NM_010593
RefSeq (protein)	NP_002221 NP_068831	NP_034723.1 NP_034723
Location (UCSC)	Chr 17: 41.75 – 41.79 Mb	Chr 11: 100.37 – 100.4 Mb
PubMed search

3IFQ

3728

16480

ENSG00000173801

ENSMUSG00000001552

P14923

Q02257

NM_002230
NM_021991

NM_010593

NP_002221
NP_068831

NP_034723.1
NP_034723

Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. Plakoglobin is a member of the catenin protein family and homologous to β-catenin. Plakoglobin is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in plakoglobin are associated with arrhythmogenic right ventricular dysplasia.

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