Pituitary-specific positive transcription factor 1

POU1F1
Identifiers
Aliases	POU1F1, CPHD1, GHF-1, PIT1, POU1F1a, Pit-1, POU class 1 homeobox 1
External IDs	OMIM: 173110 MGI: 97588 HomoloGene: 259 GeneCards: POU1F1
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • transcription corepressor activity • RNA polymerase II activating transcription factor binding • RNA polymerase II transcription factor binding • RNA polymerase II transcription coactivator activity • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • chromatin binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcription factor binding Cellular component • nucleus • transcription factor complex Biological process • negative regulation of cell proliferation • somatotropin secreting cell development • adenohypophysis development • positive regulation of inositol trisphosphate biosynthetic process • regulation of insulin-like growth factor receptor signaling pathway • pituitary gland development • regulation of transcription, DNA-templated • cell fate specification • B cell differentiation • positive regulation of cell proliferation • positive regulation of transcription, DNA-templated • determination of adult lifespan • positive regulation of transcription from RNA polymerase II promoter • positive regulation of multicellular organism growth • nuclear transport • negative regulation of transcription from RNA polymerase II promoter • somatotropin secreting cell differentiation • transcription, DNA-templated • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5449	18736
Ensembl	ENSG00000064835	ENSMUSG00000004842
UniProt	P28069	Q00286
RefSeq (mRNA)	NM_001122757 NM_000306	NM_008849
RefSeq (protein)	NP_000297 NP_001116229	NP_032875.1 NP_032875
Location (UCSC)	Chr 3: 87.26 – 87.28 Mb	Chr 16: 65.52 – 65.54 Mb
PubMed search

5449

18736

ENSG00000064835

ENSMUSG00000004842

P28069

Q00286

NM_001122757
NM_000306

NM_008849

NP_000297
NP_001116229

NP_032875.1
NP_032875

POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone.

PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.[supplied by OMIM]

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Wikipedia