The Pine Creek Path was a major Native American trail in the U.S. State of Pennsylvania that ran north along Pine Creek from the West Branch Susquehanna River near Long Island (modern-day Jersey Shore) to the headwaters of the Genesee River (in modern-day Genesee Township, Pennsylvania).
At the southern end of the trail there was a Native American village at the site of Jersey Shore and the Great Shamokin Path ran east–west here along the West Branch Susquehanna River. The Great Shamokin Path connected the Saponi village of Shamokin (modern Sunbury) on the Susquehanna River in the east, with the Great Island (modern Lock Haven) and villages further west (what are now the boroughs of Clearfield and Kittanning) and the Allegheny River. In the north another path continued north along the Genesee River and led to the Iroquois Nation in New York.
The main Pine Creek Path followed Pine Creek north, switching banks until it reached the First Fork (modern Little Pine Creek at the village of Waterville). From there it stayed on the left bank the rest of its course along Pine Creek, passing through the Pine Creek Gorge to the Second Fork (Babb Creek at Blackwell) and on to the Third Fork (modern Marsh Creek) and the village of Ansonia. There it left the gorge and turned west, going past modern Galeton to West Pike, where it left the creek and headed north to the Genesee River. The exact course of the path between West Pike and the headwaters of the Genesee River are uncertain. In the south, an alternate branch (west of the main path) led north from the West Branch Susquehanna River along Chatham Run, past modern Woolrich to the main path near Waterville.