Pargyline

Pargyline
Clinical data


MedlinePlus	a682088
ATC code	C02KC01 (WHO) C02LL01 (WHO)
Identifiers
IUPAC name N-benzyl-N-methylprop-2-yn-1-amine
CAS Number	555-57-7^Y
PubChem CID	4688
IUPHAR/BPS	7262
DrugBank	DB01626^N
ChemSpider	4526^Y
UNII	9MV14S8G3E
ChEMBL	CHEMBL673^Y
ECHA InfoCard	100.008.275
Chemical and physical data
Formula	C₁₁H₁₃N
Molar mass	159.23 g/mol
3D model (Jmol)	Interactive image
SMILES C#CCN(C)Cc1ccccc1
InChI InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3^Y Key:DPWPWRLQFGFJFI-UHFFFAOYSA-N^Y
^NY (what is this?)

Pargyline (brand name Eutonyl) is an irreversible selective monoamine oxidase (MAO)-B inhibitor drug (IC₅₀ for MAO-A is 0.01152 µmol/L and for MAO-B is 0.00820 µmol/L) It was brought to market in the US and the UK by Abbott in 1963 as an antihypertensive drug branded "Eutonyl". It was one of several MAO inhibitors introduced in the 1960s including nialamide, isocarboxazid, phenelzine, and tranylcypromine. By 2007 the drug was discontinued and as of 2014 there were no generic versions available in the US. In addition to its actions as an MAOI, pargyline has been found to bind with high affinity to the I₂ imidazoline receptor (an allosteric site on the MAO enzyme).

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