Paeonol

Paeonol

Names
IUPAC name 1-(2-Hydroxy-4-methoxyphenyl)ethanone
Other names 2'-Hydroxy-4'-methoxyacetophenone 1-(2-Hydroxy-4-methoxyphenyl)ethan-1-one
Identifiers
CAS Number	552-41-0
3D model (JSmol)	Interactive image
ChemSpider	10621
ECHA InfoCard	100.008.194
PubChem CID	11092
InChI InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3 Key: UILPJVPSNHJFIK-UHFFFAOYSA-N InChI=1/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3 Key: UILPJVPSNHJFIK-UHFFFAOYAG
SMILES CC(=O)C1=C(C=C(C=C1)OC)O
Properties
Chemical formula	C9H10O3
Molar mass	166.18 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Paeonol is a phenolic compound found in peonies such as Paeonia suffruticosa (moutan cortex), in Arisaema erubescens, and in Dioscorea japonica. It is a component found in some Traditional Chinese medicine remedies.

A number of biological effects of paeonol in vitro or in animal models have been observed. Paeonol increases levels of cortical and vascular actin and improves behavior in a rat model of Alzheimer's disease. Paeonol also reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats.

Paeonol shows antimutagenic activities. It also has anti-inflammatory and analgesic effects in carrageenan-evoked thermal hyperalgesia. Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α.

Paeonol has MAO-A and MAO-B inhibiting effects with IC₅₀ values of 54.6 μM and 42.5 μM respectively.