PTPRM

PTPRM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RPM, 2C9A, 2V5Y
Identifiers
Aliases	PTPRM, PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu, protein tyrosine phosphatase, receptor type M
External IDs	MGI: 102694 HomoloGene: 37694 GeneCards: PTPRM
Gene ontology Molecular function • phosphoprotein phosphatase activity • phosphatase activity • cadherin binding • protein binding • identical protein binding • protein tyrosine phosphatase activity • transmembrane receptor protein tyrosine phosphatase activity • hydrolase activity Cellular component • cytoplasm • integral component of membrane • membrane • cell-cell junction • integral component of plasma membrane • cell-cell adherens junction • perinuclear region of cytoplasm • lamellipodium • plasma membrane Biological process • dephosphorylation • retina layer formation • protein dephosphorylation • negative regulation of endothelial cell migration • negative regulation of endothelial cell proliferation • cell adhesion • negative regulation of angiogenesis • neuron projection development • response to drug • signal transduction • homophilic cell adhesion via plasma membrane adhesion molecules • retinal ganglion cell axon guidance • peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5797	19274
Ensembl	ENSG00000173482	ENSMUSG00000033278
UniProt	P28827	P28828
RefSeq (mRNA)	NM_001105244 NM_002845	NM_008984
RefSeq (protein)	NP_001098714 NP_002836	NP_033010.2 NP_033010
Location (UCSC)	Chr 18: 7.57 – 8.41 Mb	Chr 17: 66.67 – 67.35 Mb
PubMed search

1RPM, 2C9A, 2V5Y

5797

19274

ENSG00000173482

ENSMUSG00000033278

P28827

P28828

NM_001105244
NM_002845

NM_008984

NP_001098714
NP_002836

NP_033010.2
NP_033010

Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the PTPRM gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases are protein enzymes that remove phosphate moieties from tyrosine residues on other proteins. Tyrosine kinases are enzymes that add phosphates to tyrosine residues, and are the opposing enzymes to PTPs. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPs can be both cytosolic and transmembrane.

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