PTPN21

PTPN21
Identifiers
Aliases	PTPN21, PTPD1, PTPRL10, protein tyrosine phosphatase, non-receptor type 21
External IDs	MGI: 1344406 HomoloGene: 5110 GeneCards: PTPN21
Gene ontology Molecular function • phosphoprotein phosphatase activity • hydrolase activity • phosphatase activity • protein binding • protein tyrosine phosphatase activity Cellular component • cytoplasm • cytoskeleton Biological process • protein dephosphorylation • dephosphorylation • peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11099	24000
Ensembl	ENSG00000070778	ENSMUSG00000021009
UniProt	Q16825	Q62136
RefSeq (mRNA)	NM_007039	NM_001146199 NM_011877
RefSeq (protein)	NP_008970	n/a
Location (UCSC)	Chr 14: 88.47 – 88.55 Mb	Chr 12: 98.68 – 98.74 Mb
PubMed search

11099

24000

ENSG00000070778

ENSMUSG00000021009

Q16825

Q62136

NM_007039

NM_001146199
NM_011877

NP_008970

n/a

Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.

PTPN21 has been shown to interact with BMX and KIF1C.

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