PREX1

PREX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QIK, 4YON, 5D3W, 5D3V, 5FI0, 5D27, 5D3Y, 5FI1, 5D3X
Identifiers
Aliases	PREX1, P-REX1, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
External IDs	MGI: 3040696 HomoloGene: 10821 GeneCards: PREX1
Gene ontology Molecular function • GTPase activator activity • protein binding • Rho guanyl-nucleotide exchange factor activity • enzyme binding • phospholipid binding • guanyl-nucleotide exchange factor activity • Rac guanyl-nucleotide exchange factor activity Cellular component • membrane • growth cone • plasma membrane • dendritic shaft • perinuclear region of cytoplasm • cytoplasm • cytosol Biological process • intracellular signal transduction • neutrophil activation • regulation of dendrite development • neutrophil chemotaxis • reactive oxygen species metabolic process • regulation of actin filament polymerization • actin filament polymerization • positive regulation of GTPase activity • positive regulation of substrate adhesion-dependent cell spreading • T cell differentiation • regulation of Rho protein signal transduction • superoxide metabolic process • positive regulation of cell adhesion • negative regulation of protein kinase activity • G-protein coupled receptor signaling pathway • positive regulation of cell migration • negative regulation of TOR signaling • positive regulation of apoptotic process • regulation of small GTPase mediated signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57580	277360
Ensembl	ENSG00000124126	ENSMUSG00000039621
UniProt	Q8TCU6	Q69ZK0
RefSeq (mRNA)	NM_020820	NM_177782
RefSeq (protein)	NP_065871	NP_808450
Location (UCSC)	Chr 20: 48.62 – 48.83 Mb	Chr 2: 166.57 – 166.71 Mb
PubMed search

3QIK, 4YON, 5D3W, 5D3V, 5FI0, 5D27, 5D3Y, 5FI1, 5D3X

57580

277360

ENSG00000124126

ENSMUSG00000039621

Q8TCU6

Q69ZK0

NM_020820

NM_177782

NP_065871

NP_808450

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein is a protein that in humans is encoded by the PREX1 gene.

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.

...
Wikipedia