RAC1

RAC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E96, 1FOE, 1G4U, 1HE1, 1HH4, 1I4D, 1I4L, 1I4T, 1MH1, 1RYF, 1RYH, 2FJU, 2H7V, 2NZ8, 2P2L, 2RMK, 2VRW, 2WKP, 2WKQ, 2WKR, 2YIN, 3B13, 3BJI, 3RYT, 3SBD, 3SBE, 3SU8, 3SUA, 3TH5, 4GZL, 4GZM, 4YON, 5FI0
Identifiers
Aliases	RAC1, MIG5, Rac-1, TC-25, p21-Rac1, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
External IDs	OMIM: 602048 MGI: 97845 HomoloGene: 69035 GeneCards: RAC1
Gene ontology Molecular function • histone deacetylase binding • Rho GDP-dissociation inhibitor binding • GTP-dependent protein binding • GTPase activity • enzyme binding • protein binding • thioesterase binding • protein kinase binding • nucleotide binding • GTP binding • Rab GTPase binding Cellular component • cytoplasm • cytosol • membrane • focal adhesion • melanosome • ruffle membrane • trans-Golgi network • nucleus • cell projection • extrinsic component of plasma membrane • extracellular exosome • lamellipodium • early endosome membrane • plasma membrane • actin filament • cytoplasmic ribonucleoprotein granule • endoplasmic reticulum membrane • Golgi membrane • cytoplasmic, membrane-bounded vesicle • phagocytic cup • cytoplasmic vesicle • extracellular matrix Biological process • positive regulation of Rho protein signal transduction • regulation of respiratory burst • movement of cell or subcellular component • non-canonical Wnt signaling pathway • positive regulation of protein phosphorylation • positive regulation of actin filament polymerization • regulation of neuron maturation • negative regulation of receptor-mediated endocytosis • platelet activation • Fc-epsilon receptor signaling pathway • cellular response to mechanical stimulus • phagocytosis, engulfment • vascular endothelial growth factor receptor signaling pathway • substrate adhesion-dependent cell spreading • cell proliferation • ruffle assembly • lamellipodium assembly • dopaminergic neuron differentiation • cell-cell junction organization • Fc-gamma receptor signaling pathway involved in phagocytosis • ruffle organization • actin filament organization • cell motility • anatomical structure morphogenesis • bone resorption • response to wounding • protein localization to plasma membrane • inflammatory response • regulation of small GTPase mediated signal transduction • positive regulation of cell-substrate adhesion • G-protein coupled receptor signaling pathway • neuron projection morphogenesis • epithelial cell morphogenesis • dendrite morphogenesis • regulation of hydrogen peroxide metabolic process • engulfment of apoptotic cell • dendrite development • auditory receptor cell morphogenesis • hyperosmotic response • cerebral cortex GABAergic interneuron development • chemotaxis • positive regulation of DNA replication • actin filament polymerization • cell adhesion • negative regulation of interleukin-23 production • homeostasis of number of cells within a tissue • cell-matrix adhesion • localization within membrane • actin cytoskeleton organization • regulation of cell size • anatomical structure arrangement • intracellular signal transduction • regulation of cell migration • endocytosis • ephrin receptor signaling pathway • T cell costimulation • blood coagulation • regulation of defense response to virus by virus • synaptic transmission, GABAergic • mast cell chemotaxis • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of substrate adhesion-dependent cell spreading • embryonic olfactory bulb interneuron precursor migration • cytoskeleton organization • cochlea morphogenesis • positive regulation of neutrophil chemotaxis • positive regulation of apoptotic process • regulation of cell morphogenesis • positive regulation of focal adhesion assembly • regulation of fibroblast migration • positive regulation of lamellipodium assembly • cerebral cortex radially oriented cell migration • cell migration • semaphorin-plexin signaling pathway • positive regulation of stress fiber assembly • axon guidance • small GTPase mediated signal transduction • positive regulation of GTPase activity • Wnt signaling pathway, planar cell polarity pathway • midbrain dopaminergic neuron differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5879	19353
Ensembl	ENSG00000136238	ENSMUSG00000001847
UniProt	P63000	P63001
RefSeq (mRNA)	NM_198829 NM_006908 NM_018890	NM_009007 NM_001347530
RefSeq (protein)	NP_008839 NP_061485	NP_033033.1 NP_001334459 NP_033033
Location (UCSC)	Chr 7: 6.37 – 6.4 Mb	Chr 5: 143.5 – 143.53 Mb
PubMed search

1E96, 1FOE, 1G4U, 1HE1, 1HH4, 1I4D, 1I4L, 1I4T, 1MH1, 1RYF, 1RYH, 2FJU, 2H7V, 2NZ8, 2P2L, 2RMK, 2VRW, 2WKP, 2WKQ, 2WKR, 2YIN, 3B13, 3BJI, 3RYT, 3SBD, 3SBE, 3SU8, 3SUA, 3TH5, 4GZL, 4GZM, 4YON, 5FI0

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