PPP3CC

Identifiers

PPP3CC, CALNA3, CNA3, PP2Bgamma, protein phosphatase 3 catalytic subunit gamma

External IDs

MGI: 107162 HomoloGene: 68475 GeneCards: PPP3CC

Gene location (Human)

Chr.	Chromosome 8 (human)

Band	8p21.3	Start	22,440,819 bp
Band	8p21.3	End	22,541,142 bp

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)

Band	14\|14 D2	Start	70,217,898 bp
Band	14\|14 D2	End	70,289,449 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• phosphoprotein phosphatase activity • protein binding • hydrolase activity • metal ion binding • calmodulin binding
Cellular component	• cytosol • extracellular exosome • mitochondrion
Biological process	• positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • protein dephosphorylation • brain development
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5533


19057

Ensembl


ENSG00000120910


ENSMUSG00000022092

UniProt


P48454


P48455

RefSeq (mRNA)


NM_001243974 NM_001243975 NM_005605


NM_008915 NM_001304991 NM_001304992

RefSeq (protein)


NP_001230903 NP_001230904 NP_005596


NP_001291920 NP_001291921 NP_032941

Location (UCSC)

Chr 8: 22.44 – 22.54 Mb

Chr 8: 70.22 – 70.29 Mb

PubMed search

NM_001243974
NM_001243975
NM_005605

NM_008915
NM_001304991
NM_001304992

NP_001230903
NP_001230904
NP_005596

NP_001291920
NP_001291921
NP_032941

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PP2BC) is an enzyme that in humans is encoded by the PPP3CC gene.

Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM]

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