POU3F4

POU3F4
Identifiers
Aliases	POU3F4, BRAIN-4, BRN-4, BRN4, DFN3, DFNX2, OCT-9, OTF-9, OTF9, POU class 3 homeobox 4
External IDs	MGI: 101894 HomoloGene: 260 GeneCards: POU3F4
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • double-stranded DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • AT DNA binding Cellular component • intracellular • nucleus Biological process • regulation of transcription from RNA polymerase II promoter • negative regulation of mesenchymal cell apoptotic process • inner ear development • brain development • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • sensory perception of sound • cochlea morphogenesis • transcription, DNA-templated • forebrain neuron differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5456	18994
Ensembl	ENSG00000196767	ENSMUSG00000056854
UniProt	P49335	P62515
RefSeq (mRNA)	NM_000307	NM_008901
RefSeq (protein)	NP_000298	NP_032927
Location (UCSC)	Chr X: 83.51 – 83.51 Mb	Chr X: 110.81 – 110.82 Mb
PubMed search

5456

18994

ENSG00000196767

ENSMUSG00000056854

P49335

P62515

NM_000307

NM_008901

NP_000298

NP_032927

POU domain, class 3, transcription factor 4 is a protein that in humans is encoded by the POU3F4 gene found on the X chromosome.

POU3F4 is involved in the patterning of the neural tube and both the paraventricular and supraoptic nuclei of the hypothalamus in the developing embryo. During development, POU3F4 is also expressed in the mesenchyme of the periotic bone surrounding the inner ear. A “knockout” mice model displayed that alteration to the POU3F4 gene interrupted this mesenchymal cell differentiation in the superior semicircular canal. The deformities observed in mice were similar to those in humans with X-linked non-syndromic deafness (DFN-3).

...
Wikipedia