PLXNB3

PLXNB3
Identifiers
Aliases	PLXNB3, PLEXB3, PLEXR, PLXN6, plexin B3
External IDs	MGI: 2154240 HomoloGene: 68468 GeneCards: PLXNB3
Gene location (Human) Chr. X chromosome (human) Band Xq28 Start 153,764,196 bp End 153,779,346 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band n/a Start 73,757,090 bp End 73,772,514 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • semaphorin receptor activity • Rho GDP-dissociation inhibitor binding • protein domain specific binding • protein binding • protein binding involved in cell-cell adhesion Cellular component • integral component of membrane • membrane • cell membrane • cell surface Biological process • negative regulation of cell adhesion • positive regulation of endothelial cell proliferation • positive regulation of axonogenesis • nervous system development • negative regulation of cell migration • negative regulation of GTPase activity • regulation of cell shape • cell chemotaxis • positive chemotaxis • semaphorin-plexin signaling pathway • signal transduction • negative regulation of lamellipodium assembly • positive regulation of neuron projection development • homophilic cell adhesion via plasma membrane adhesion molecules • axon extension Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5365	140571
Ensembl	ENSG00000198753	ENSMUSG00000031385
UniProt	Q9ULL4	Q9QY40
RefSeq (mRNA)	NM_005393 NM_001163257	NM_019587
RefSeq (protein)	NP_001156729 NP_005384	NP_062533
Location (UCSC)	Chr X: 153.76 – 153.78 Mb	Chr X: 73.76 – 73.77 Mb
PubMed search

5365

140571

ENSG00000198753

ENSMUSG00000031385

Q9ULL4

Q9QY40

NM_005393
NM_001163257

NM_019587

NP_001156729
NP_005384

NP_062533

Plexin-B3 is a protein that in humans is encoded by the PLXNB3 gene.

PLXNB3 has been shown to interact with ARHGEF11.

Model organisms have been used in the study of PLXNB3 function. A conditional knockout mouse line called Plxnb3^{tm1a(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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