ARHGEF11

ARHGEF11
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1HTJ, 1XCG, 2DLS, 3KZ1, 3T06, 5E6P
Identifiers
Aliases	ARHGEF11, GTRAP48, PDZ-RHOGEF, Rho guanine nucleotide exchange factor 11
External IDs	MGI: 2441869 HomoloGene: 11409 GeneCards: ARHGEF11
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.1 Start 156,934,840 bp End 157,045,370 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band n/a Start 87,617,559 bp End 87,738,034 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • GTPase activator activity • protein binding • Rho guanyl-nucleotide exchange factor activity • G-protein coupled receptor binding • guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cytosol • membrane • intracellular Biological process • G-protein coupled receptor signaling pathway • movement of cell or subcellular component • cytokinesis • positive regulation of transcription, DNA-templated • regulation of cell growth • Rho protein signal transduction • establishment of cell polarity • positive regulation of apoptotic process • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • striated muscle contraction • actin cytoskeleton organization • positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9826	213498
Ensembl	ENSG00000132694	ENSMUSG00000041977
UniProt	O15085	n/a
RefSeq (mRNA)	NM_014784 NM_198236	NM_001003912
RefSeq (protein)	NP_055599 NP_937879	n/a
Location (UCSC)	Chr 1: 156.93 – 157.05 Mb	Chr 1: 87.62 – 87.74 Mb
PubMed search

1HTJ, 1XCG, 2DLS, 3KZ1, 3T06, 5E6P

9826

213498

ENSG00000132694

ENSMUSG00000041977

O15085

n/a

NM_014784
NM_198236

NM_001003912

NP_055599
NP_937879

n/a

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

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