PIKFYVE

PIKFYVE
Identifiers
Aliases	PIKFYVE, CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29, phosphoinositide kinase, FYVE-type zinc finger containing
External IDs	MGI: 1335106 HomoloGene: 32115 GeneCards: PIKFYVE
Gene ontology Molecular function • transferase activity • nucleotide binding • zinc ion binding • 1-phosphatidylinositol-4-phosphate 5-kinase activity • metal ion binding • kinase activity • protein binding • phosphatidylinositol phosphate kinase activity • ATP binding • phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity • 1-phosphatidylinositol-3-phosphate 5-kinase activity • protein binding involved in protein folding • unfolded protein binding Cellular component • cytosol • endosome • early endosome membrane • membrane • late endosome membrane • cell-cell junction • vesicle membrane • Golgi membrane • perinuclear region of cytoplasm • membrane raft • endosome membrane • cytoplasmic vesicle Biological process • GO:0007242 intracellular signal transduction • phosphatidylinositol metabolic process • phosphorylation • myelin assembly • receptor-mediated endocytosis • regulation of autophagosome assembly • phosphatidylinositol phosphorylation • retrograde transport, endosome to Golgi • phosphatidylinositol 5-phosphate metabolic process • protein localization to nucleus • phosphatidylinositol biosynthetic process • phosphatidylinositol-3-phosphate biosynthetic process • 'de novo' protein folding • chaperone-mediated protein folding Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	200576	18711
Ensembl	ENSG00000115020	ENSMUSG00000025949
UniProt	Q9Y2I7	Q9Z1T6
RefSeq (mRNA)	NM_001002881 NM_001178000 NM_015040 NM_152671	NM_011086 NM_001310624
RefSeq (protein)	NP_001171471 NP_055855 NP_689884	NP_001297553 NP_035216
Location (UCSC)	Chr 2: 208.27 – 208.36 Mb	Chr 1: 65.19 – 65.28 Mb
PubMed search

200576

18711

ENSG00000115020

ENSMUSG00000025949

Q9Y2I7

Q9Z1T6

NM_001002881
NM_001178000
NM_015040
NM_152671

NM_011086
NM_001310624

NP_001171471
NP_055855
NP_689884

NP_001297553
NP_035216

PIKfyve, a FYVE finger-containing phosphoinositide kinase, is an enzyme that in humans is encoded by the PIKFYVE gene.

The principal enzymatic activity of PIKfyve is to phosphorylate PtdIns3P to PtdIns(3,5)P2. PIKfyve activity is responsible for the production of both PtdIns(3,5)P2 and phosphatidylinositol 5-phosphate (PtdIns5P). PIKfyve is a large protein, containing a number of functional domains and expressed in several spliced forms. The reported full-length mouse and human cDNA clones encode proteins of 2052 and 2098 amino acid residues, respectively. By directly binding membrane PtdIns(3)P, the FYVE finger domain of PIKfyve is essential in localizing the protein to the cytosolic leaflet of endosomes. Impaired PIKfyve enzymatic activity by dominant-interfering mutants, siRNA- mediated ablation or pharmacological inhibition causes endosome enlargement and cytoplasmic vacuolation due to impaired PtdIns(3,5)P2 synthesis. Thus, via PtdIns(3,5)P2 production, PIKfyve participates in several aspects of endosome dynamics, thereby affecting a number of trafficking pathways that emanate from or traverse the endosomal system en route to the trans-Golgi network or later compartments along the endocytic pathway.

...
Wikipedia