PIK3CG

PIK3CG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E8Y, 1E8Z, 1HE8, 2A4Z, 2A5U, 2CHW, 2CHX, 2CHZ, 2V4L, 3APC, 3APD, 3APF, 3CSF, 3CST, 3DBS, 3ENE, 3IBE, 3L08, 3L13, 3L16, 3L17, 3L54, 3LJ3, 3MJW, 3ML8, 3ML9, 3NZS, 3NZU, 3OAW, 3P2B, 3PRE, 3PRZ, 3PS6, 3QAQ, 3QAR, 3QJZ, 3QK0, 3R7Q, 3R7R, 3S2A, 3SD5, 3T8M, 3TJP, 3TL5, 3ZVV, 3ZW3, 4ANU, 4ANV, 4ANW, 4ANX, 4AOF, 4DK5, 4EZJ, 4EZK, 4EZL, 4F1S, 4FA6, 4FAD, 4FHJ, 4FHK, 4FJY, 4FJZ, 4FLH, 4FUL, 4G11, 4GB9, 4HLE, 4HVB, 4J6I, 4KZ0, 4KZC, 4PS3, 4PS7, 4PS8, 4URK, 4WWN, 4WWO, 4WWP, 4XX5, 4XZ4, 5EDS, 5G2N
Identifiers
Aliases	PIK3CG, PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
External IDs	MGI: 1353576 HomoloGene: 68269 GeneCards: PIK3CG
EC number	2.7.11.1
Targeted by Drug
dactolisib, idelalisib, ly-294002
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • ephrin receptor binding • 1-phosphatidylinositol-4-phosphate 3-kinase activity • protein serine/threonine kinase activity • protein binding • phosphatidylinositol 3-kinase activity • ATP binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • kinase activity • 1-phosphatidylinositol-3-kinase activity Cellular component • cytoplasm • phosphatidylinositol 3-kinase complex • membrane • phosphatidylinositol 3-kinase complex, class IB • cytosol • mast cell granule • plasma membrane Biological process • regulation of protein phosphorylation • G-protein coupled receptor signaling pathway • positive regulation of protein kinase B signaling • regulation of cell adhesion mediated by integrin • endocytosis • adaptive immune response • respiratory burst involved in defense response • positive regulation of MAP kinase activity • immune system process • positive regulation of cytosolic calcium ion concentration • T cell chemotaxis • cytokine production • positive regulation of catalytic activity • secretory granule localization • dendritic cell chemotaxis • neutrophil chemotaxis • platelet activation • T cell proliferation • chemotaxis • protein phosphorylation • phosphatidylinositol-3-phosphate biosynthetic process • phosphatidylinositol phosphorylation • natural killer cell chemotaxis • angiogenesis • positive regulation of acute inflammatory response • phosphatidylinositol biosynthetic process • negative regulation of fibroblast apoptotic process • phosphatidylinositol 3-kinase signaling • negative regulation of triglyceride catabolic process • mast cell degranulation • inflammatory response • innate immune response • platelet aggregation • neutrophil extravasation • T cell activation • regulation of calcium ion transmembrane transport • cellular response to cAMP • hepatocyte apoptotic process • phosphatidylinositol-mediated signaling • negative regulation of cardiac muscle contraction • phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5294	30955
Ensembl	ENSG00000105851	ENSMUSG00000020573
UniProt	P48736	Q9JHG7
RefSeq (mRNA)	NM_001282426 NM_001282427 NM_002649	NM_001146200 NM_001146201 NM_020272
RefSeq (protein)	NP_001269355 NP_001269356 NP_002640	NP_001139672.1 NP_001139673.1 NP_064668.2 NP_001139672 NP_001139673 NP_064668
Location (UCSC)	Chr 7: 106.87 – 106.91 Mb	Chr 12: 32.17 – 32.21 Mb
PubMed search

1E8Y, 1E8Z, 1HE8, 2A4Z, 2A5U, 2CHW, 2CHX, 2CHZ, 2V4L, 3APC, 3APD, 3APF, 3CSF, 3CST, 3DBS, 3ENE, 3IBE, 3L08, 3L13, 3L16, 3L17, 3L54, 3LJ3, 3MJW, 3ML8, 3ML9, 3NZS, 3NZU, 3OAW, 3P2B, 3PRE, 3PRZ, 3PS6, 3QAQ, 3QAR, 3QJZ, 3QK0, 3R7Q, 3R7R, 3S2A, 3SD5, 3T8M, 3TJP, 3TL5, 3ZVV, 3ZW3, 4ANU, 4ANV, 4ANW, 4ANX, 4AOF, 4DK5, 4EZJ, 4EZK, 4EZL, 4F1S, 4FA6, 4FAD, 4FHJ, 4FHK, 4FJY, 4FJZ, 4FLH, 4FUL, 4G11, 4GB9, 4HLE, 4HVB, 4J6I, 4KZ0, 4KZC, 4PS3, 4PS7, 4PS8, 4URK, 4WWN, 4WWO, 4WWP, 4XX5, 4XZ4, 5EDS, 5G2N

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