PICK1

PICK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GZV
Identifiers
Aliases	PICK1, PICK, PRKCABP, protein interacting with PRKCA 1
External IDs	MGI: 894645 HomoloGene: 7470 GeneCards: PICK1
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.1 Start 38,056,311 bp End 38,075,701 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 79,229,173 bp End 79,256,674 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein domain specific binding • Arp2/3 complex binding • metal ion binding • actin filament binding • protein C-terminus binding • protein binding • identical protein binding • enzyme binding • actin binding • receptor binding • G-protein coupled receptor binding • protein kinase C binding Cellular component • cytoplasm • endocytic vesicle membrane • postsynaptic membrane • Golgi apparatus • postsynaptic density • membrane • plasma membrane • synapse • cell junction • perinuclear region of cytoplasm • neuron projection • cytoskeleton • presynaptic membrane • mitochondrion • cytosol • aggresome Biological process • cellular response to glucose starvation • glial cell development • retrograde vesicle-mediated transport, Golgi to ER • positive regulation of receptor internalization • neuronal ion channel clustering • regulation of Arp2/3 complex-mediated actin nucleation • monoamine transport • receptor clustering • DNA methylation involved in gamete generation • negative regulation of Arp2/3 complex-mediated actin nucleation • dendritic spine organization • dendritic spine maintenance • protein phosphorylation • protein kinase C-activating G-protein coupled receptor signaling pathway • long term synaptic depression • cellular response to decreased oxygen levels • DNA methylation involved in embryo development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9463	18693
Ensembl	ENSG00000100151	ENSMUSG00000068206
UniProt	Q9NRD5	Q62083
RefSeq (mRNA)	NM_001039583 NM_001039584 NM_012407	NM_001045558 NM_008837
RefSeq (protein)	NP_001034672 NP_001034673 NP_036539 NP_001034672.1 NP_001034673.1 NP_036539.1	n/a
Location (UCSC)	Chr 22: 38.06 – 38.08 Mb	Chr 22: 79.23 – 79.26 Mb
PubMed search

2GZV

9463

18693

ENSG00000100151

ENSMUSG00000068206

Q9NRD5

Q62083

NM_001039583
NM_001039584
NM_012407

NM_001045558
NM_008837

NP_036539.1

n/a

Protein Interacting with C Kinase - 1 is a protein that in humans is encoded by the PICK1 gene.

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.

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