PKC alpha

PRKCA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ELI, 3IW4, 4DNL, 4RA4
Identifiers
Aliases	PRKCA, AAG6, PKC-alpha, PKCA, PRKACA, protein kinase C alpha
External IDs	OMIM: 176960 MGI: 97595 HomoloGene: 55679 GeneCards: PRKCA
Genetically Related Diseases
coronary artery disease, post-traumatic stress disorder
Targeted by Drug
ingenol mebutate, balanol, enzastaurin, ruboxistaurin
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • protein kinase C activity • zinc ion binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein binding • enzyme binding • histone kinase activity (H3-T6 specific) • ATP binding • calcium-dependent protein kinase C activity Cellular component • cytoplasm • cytosol • mitochondrial membrane • membrane • plasma membrane • nucleoplasm • endoplasmic reticulum • mitochondrion • perinuclear region of cytoplasm • extracellular exosome • nucleus Biological process • apoptotic process • negative regulation of adenylate cyclase activity • intracellular signal transduction • response to interleukin-1 • positive regulation of endothelial cell proliferation • histone H3-T6 phosphorylation • regulation of mRNA stability • regulation of insulin secretion • phosphorylation • positive regulation of cell migration • negative regulation of glial cell apoptotic process • positive regulation of macrophage differentiation • positive regulation of mitotic cell cycle • activation of adenylate cyclase activity • positive regulation of angiogenesis • positive regulation of cardiac muscle hypertrophy • positive regulation of endothelial cell migration • platelet activation • positive regulation of lipopolysaccharide-mediated signaling pathway • protein phosphorylation • mitotic nuclear envelope disassembly • desmosome assembly • cell adhesion • peptidyl-serine phosphorylation • angiogenesis • positive regulation of blood vessel endothelial cell migration • positive regulation of ERK1 and ERK2 cascade • apoptotic signaling pathway • positive regulation of dense core granule biogenesis • regulation of platelet aggregation • positive regulation of cell adhesion • axon guidance • ERBB2 signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5578	18750
Ensembl	ENSG00000154229	ENSMUSG00000050965
UniProt	P17252	P20444
RefSeq (mRNA)	NM_002737	NM_011101
RefSeq (protein)	NP_002728	NP_035231.2 NP_035231
Location (UCSC)	Chr 17: 66.3 – 66.81 Mb	Chr 11: 107.93 – 108.34 Mb
PubMed search

2ELI, 3IW4, 4DNL, 4RA4

5578

18750

ENSG00000154229

ENSMUSG00000050965

P17252

P20444

NM_002737

NM_011101

NP_002728

NP_035231.2
NP_035231

Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca²⁺ handling in myocytes.

...
Wikipedia