PER2

PER2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GDI, 4CT0, 4U8H
Identifiers
Aliases	PER2, FASPS, FASPS1, period circadian clock 2
External IDs	OMIM: 603426 MGI: 1195265 HomoloGene: 7885 GeneCards: PER2
Gene ontology Molecular function • transcription factor activity, transcription factor binding • transcription coactivator activity • transcription regulatory region sequence-specific DNA binding • ubiquitin binding • protein binding Cellular component • nucleolus • perinuclear region of cytoplasm • nucleus • cytoplasm Biological process • histone H3 deacetylation • gluconeogenesis • regulation of transcription, DNA-templated • regulation of insulin secretion • rhythmic process • negative regulation of fat cell proliferation • negative regulation of circadian rhythm • negative regulation of transcription from RNA polymerase II promoter • circadian regulation of gene expression • transcription, DNA-templated • fatty acid metabolic process • regulation of cell cycle • negative regulation of protein ubiquitination • circadian regulation of translation • response to ischemia • regulation of vasoconstriction • glycogen biosynthetic process • negative regulation of transcription regulatory region DNA binding • regulation of circadian rhythm • circadian rhythm • white fat cell differentiation • regulation of glutamate uptake involved in transmission of nerve impulse • lactate biosynthetic process • negative regulation of transcription, DNA-templated • regulation of neurogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8864	18627
Ensembl	ENSG00000132326	ENSMUSG00000055866
UniProt	O15055	O54943
RefSeq (mRNA)	NM_003894 NM_022817	NM_011066
RefSeq (protein)	NP_073728	NP_035196.2 NP_035196
Location (UCSC)	Chr 2: 238.24 – 238.29 Mb	Chr 1: 91.42 – 91.46 Mb
PubMed search

3GDI, 4CT0, 4U8H

8864

18627

ENSG00000132326

ENSMUSG00000055866

O15055

O54943

NM_003894
NM_022817

NM_011066

NP_073728

NP_035196.2
NP_035196

PER2 is a protein in mammals encoded by the PER2 gene. PER2 is noted for its major role in circadian rhythms.

The per gene was first discovered using forward genetics in Drosophilla melanogaster in 1971. This led to experiments in mammals that found Per2 in humans.

Mammalian Per2 was discovered by Albrecht U et al. in 1997 through a search for homologous CDNA sequences to PER1. It is more similar to Drosophila per than its paralogs.

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Wikipedia