PER1

PER1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UL6
Identifiers
Aliases	PER1, PER, RIGUI, hPER, period circadian clock 1
External IDs	OMIM: 602260 MGI: 1098283 HomoloGene: 1966 GeneCards: PER1
Gene ontology Molecular function • transcription factor activity, transcription factor binding • transcription factor binding • transcription regulatory region sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • E-box binding • kinase binding • chromatin DNA binding • ubiquitin protein ligase binding Cellular component • cytoplasm • nucleus • nucleoplasm • cytosol Biological process • histone H3 deacetylation • negative regulation of glucocorticoid receptor signaling pathway • regulation of transcription, DNA-templated • response to light stimulus • regulation of cytokine production involved in inflammatory response • regulation of sodium ion transport • rhythmic process • negative regulation of transcription from RNA polymerase II promoter • negative regulation of I-kappaB kinase/NF-kappaB signaling • circadian regulation of gene expression • transcription, DNA-templated • entrainment of circadian clock • negative regulation of JNK cascade • circadian regulation of translation • regulation of circadian rhythm • circadian rhythm • histone H3 acetylation • regulation of hair cycle • histone H4 acetylation • posttranscriptional regulation of gene expression • response to cAMP • regulation of p38MAPK cascade • negative regulation of transcription, DNA-templated • entrainment of circadian clock by photoperiod • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5187	18626
Ensembl	ENSG00000179094	ENSMUSG00000020893
UniProt	O15534	O35973
RefSeq (mRNA)	NM_002616	NM_001159367 NM_011065
RefSeq (protein)	NP_002607	NP_001152839.1 NP_035195.2 NP_001152839 NP_035195
Location (UCSC)	Chr 17: 8.14 – 8.16 Mb	Chr 11: 69.1 – 69.11 Mb
PubMed search

1UL6

5187

18626

ENSG00000179094

ENSMUSG00000020893

O15534

O35973

NM_002616

NM_001159367
NM_011065

NP_002607

NP_001152839.1
NP_035195.2
NP_001152839
NP_035195

The PER1 gene encodes the period circadian protein homolog 1 protein in humans.

The PER1 protein is important to the maintenance of circadian rhythms in cells, and may also play a role in the development of cancer. This gene is a member of the period family of genes. It is expressed with a daily oscillating circadian rhythm, or an oscillation that cycles with a period of approximately 24 hours. PER1 is most notably expressed in the region of the brain called the suprachiasmatic nucleus (SCN), which is the primary circadian pacemaker in the mammalian brain. PER1 is also expressed throughout mammalian peripheral tissues. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression of PER1 in the suprachiasmatic nucleus will free-run in constant darkness, meaning that the 24-hour period of the cycle will persist without the aid of external light cues. Subsequently, a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The time of gene expression is sensitive to light, as light during a mammal's subjective night results in a sudden increase in per expression and thus a shift in phase in the suprachiasmatic nucleus.Alternative splicing has been observed in this gene; however, these variants have not been fully described. There is some disagreement between experts over the occurrence of polymorphisms with functional significance. Many scientists state that there are no known polymorphisms of the human PER1 gene with significance at a population level that results in measurable behavioral or physiological changes. Still, some believe that even silent mutations can cause significant behavioral phenotypes,and result in major phase changes.

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Wikipedia