PDGFRB

PDGFRB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GQ5, 1H9O, 1SHA, 2L6W, 2PLD, 2PLE, 3MJG
Identifiers
Aliases	PDGFRB, CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1, KOGS, PENTT, platelet derived growth factor receptor beta
External IDs	MGI: 97531 HomoloGene: 1960 GeneCards: PDGFRB
Targeted by Drug
cediranib, crenolanib, linifanib, masitinib, nintedanib, pazopanib, semaxanib, sunitinib, vatalanib
Gene ontology Molecular function • vascular endothelial growth factor binding • kinase activity • platelet-derived growth factor-activated receptor activity • transmembrane receptor protein tyrosine kinase activity • receptor binding • ATP binding • protein kinase activity • platelet-derived growth factor binding • platelet activating factor receptor activity • transferase activity • platelet-derived growth factor receptor binding • protein binding • protein tyrosine kinase activity • protein kinase binding • platelet-derived growth factor beta-receptor activity • nucleotide binding • phosphatidylinositol 3-kinase binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Ras guanyl-nucleotide exchange factor activity • enzyme binding Cellular component • cytoplasm • membrane • focal adhesion • nucleus • apical plasma membrane • lysosome • extracellular exosome • integral component of membrane • plasma membrane • lysosomal lumen • intrinsic component of plasma membrane • cytoplasmic vesicle • cell surface Biological process • positive regulation of MAP kinase activity • positive regulation of phospholipase C activity • cell migration involved in vasculogenesis • cardiac myofibril assembly • positive regulation of smooth muscle cell migration • protein phosphorylation • response to lipid • positive regulation of phosphoprotein phosphatase activity • positive regulation of reactive oxygen species metabolic process • metanephric glomerular mesangial cell proliferation involved in metanephros development • positive regulation of ERK1 and ERK2 cascade • cell chemotaxis • inner ear development • metanephric S-shaped body morphogenesis • positive regulation of mitotic nuclear division • platelet-derived growth factor receptor-beta signaling pathway • positive regulation of collagen biosynthetic process • phosphatidylinositol metabolic process • transmembrane receptor protein tyrosine kinase signaling pathway • cell migration involved in coronary angiogenesis • metanephric comma-shaped body morphogenesis • positive regulation of chemotaxis • positive regulation of DNA biosynthetic process • protein autophosphorylation • platelet-derived growth factor receptor signaling pathway • response to toxic substance • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway • regulation of actin cytoskeleton organization • response to retinoic acid • phosphorylation • response to hyperoxia • retina vasculature development in camera-type eye • metanephric glomerulus morphogenesis • metanephric mesenchymal cell migration • wound healing • cellular response to platelet-derived growth factor stimulus • negative regulation of apoptotic process • response to fluid shear stress • response to estrogen • chemotaxis • metanephric mesenchyme development • response to hydrogen peroxide • phosphatidylinositol-mediated signaling • positive regulation of smooth muscle cell proliferation • response to estradiol • intracellular signal transduction • response to organic cyclic compound • smooth muscle cell chemotaxis • positive regulation of cell migration • aorta morphogenesis • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • metanephric glomerular capillary formation • multicellular organism development • positive regulation of calcium ion import • glycosaminoglycan biosynthetic process • positive regulation of cell proliferation • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • cell migration • signal transduction • positive regulation of GTPase activity • positive regulation of Rho protein signal transduction • G-protein coupled receptor signaling pathway • phosphatidylinositol phosphorylation • positive regulation of hepatic stellate cell activation • positive regulation of fibroblast proliferation • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of apoptotic process • aging • male gonad development • lung growth • negative regulation of platelet-derived growth factor receptor-beta signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5159	18596
Ensembl	ENSG00000113721	ENSMUSG00000024620
UniProt	P09619	P05622
RefSeq (mRNA)	NM_002609	NM_001146268 NM_008809
RefSeq (protein)	NP_002600	NP_001139740.1 NP_032835.2
Location (UCSC)	Chr 5: 150.11 – 150.16 Mb	Chr 18: 61.05 – 61.09 Mb
PubMed search

1GQ5, 1H9O, 1SHA, 2L6W, 2PLD, 2PLE, 3MJG

5159

18596

ENSG00000113721

ENSMUSG00000024620

P09619

P05622

NM_002609

NM_001146268
NM_008809

NP_002600

NP_001139740.1
NP_032835.2

Beta-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRB gene.

The PDGFRB gene encodes a typical receptor tyrosine kinase, which is a transmembrane protein consisting of an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. The molecular mass of the mature, glycosylated PDGFRβ protein is approximately 180 kDA.

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