PDGFB

PDGFB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PDG, 3MJG, 4HQU, 4HQX, 4QCI
Identifiers
Aliases	PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B
External IDs	MGI: 97528 HomoloGene: 74303 GeneCards: PDGFB
Gene ontology Molecular function • protein homodimerization activity • protein heterodimerization activity • chemoattractant activity • platelet-derived growth factor receptor binding • platelet-derived growth factor binding • superoxide-generating NADPH oxidase activator activity • growth factor activity • identical protein binding • collagen binding • protein binding • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • platelet alpha granule lumen • cytoplasm • extracellular region • Golgi membrane • basolateral plasma membrane • cell surface • endoplasmic reticulum lumen • membrane • extracellular matrix • extracellular space • Golgi lumen Biological process • activation of protein kinase B activity • positive regulation of DNA biosynthetic process • positive regulation of chemotaxis • cellular response to growth factor stimulus • positive regulation of protein tyrosine kinase activity • peptidyl-tyrosine phosphorylation • positive regulation of cell division • heart development • positive regulation of glomerular filtration • positive regulation of mitotic nuclear division • positive regulation of MAP kinase activity • positive regulation of metanephric mesenchymal cell migration • positive regulation of hyaluronan biosynthetic process • MAPK cascade • protein phosphorylation • positive regulation of glomerular mesangial cell proliferation • cellular response to mycophenolic acid • positive regulation of fibroblast proliferation • activation of protein kinase activity • multicellular organism development • positive regulation of protein autophosphorylation • positive regulation of reactive oxygen species metabolic process • reactive oxygen species metabolic process • negative regulation of transcription, DNA-templated • protein kinase C signaling • metanephric glomerular mesangial cell development • negative regulation of phosphatidylinositol biosynthetic process • response to wounding • positive regulation of phosphatidylinositol 3-kinase activity • cell chemotaxis • transforming growth factor beta receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • platelet degranulation • positive regulation of cell proliferation • positive regulation of DNA replication • positive regulation of gene expression • embryonic placenta development • paracrine signaling • monocyte chemotaxis • positive regulation of endothelial cell proliferation • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of calcium ion import • positive regulation of transcription, DNA-templated • peptidyl-serine phosphorylation • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway • positive regulation of blood vessel endothelial cell migration • hemopoiesis • positive regulation of cell migration • phosphatidylinositol-mediated signaling • positive regulation of peptidyl-tyrosine phosphorylation • extracellular matrix organization • negative regulation of protein binding • positive regulation of MAPK cascade • positive regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of platelet activation • phosphatidylinositol phosphorylation • positive regulation of vascular associated smooth muscle cell migration • positive chemotaxis • negative regulation of vascular smooth muscle cell differentiation • interleukin-18-mediated signaling pathway • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • negative regulation of pri-miRNA transcription from RNA polymerase II promoter • negative regulation of gene expression • positive regulation of smooth muscle cell migration • positive regulation of smooth muscle cell proliferation • positive regulation of vascular smooth muscle cell dedifferentiation • positive regulation of GTPase activity • platelet-derived growth factor receptor signaling pathway • positive regulation of vascular smooth muscle cell proliferation • negative regulation of platelet-derived growth factor receptor-beta signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5155	18591
Ensembl	ENSG00000100311	ENSMUSG00000000489
UniProt	P01127	P31240
RefSeq (mRNA)	NM_033016 NM_002608	NM_011057
RefSeq (protein)	NP_002599 NP_148937	NP_035187.2 NP_035187
Location (UCSC)	Chr 22: 39.22 – 39.24 Mb	Chr 15: 80 – 80.01 Mb
PubMed search

1PDG, 3MJG, 4HQU, 4HQX, 4QCI

5155

18591

ENSG00000100311

ENSMUSG00000000489

P01127

P31240

NM_033016
NM_002608

NM_011057

NP_002599
NP_148937

NP_035187.2
NP_035187

Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene.

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha (PDGFA) polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds.

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