PDGFA

PDGFA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MJK
Identifiers
Aliases	PDGFA, PDGF-A, PDGF1, platelet derived growth factor subunit A
External IDs	MGI: 97527 HomoloGene: 32055 GeneCards: PDGFA
Gene ontology Molecular function • collagen binding • protein homodimerization activity • platelet-derived growth factor receptor binding • protein binding • platelet-derived growth factor binding • protein heterodimerization activity • growth factor activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • endoplasmic reticulum lumen • membrane • Golgi membrane • extracellular region • microvillus • cell surface • platelet alpha granule lumen • extracellular space • Golgi lumen Biological process • hair follicle development • embryonic lung development • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway • positive regulation of protein kinase B signaling • negative chemotaxis • regulation of actin cytoskeleton organization • positive regulation of MAP kinase activity • regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling • positive regulation of cell migration • positive regulation of fibroblast proliferation • cell-cell signaling • platelet degranulation • extracellular matrix organization • regulation of DNA biosynthetic process • cell activation • MAPK cascade • positive regulation of DNA replication • negative regulation of platelet activation • multicellular organism development • positive regulation of mesenchymal cell proliferation • response to wounding • cell projection assembly • negative regulation of phosphatidylinositol biosynthetic process • angiogenesis • positive regulation of protein autophosphorylation • positive regulation of ERK1 and ERK2 cascade • regulation of smooth muscle cell migration • animal organ morphogenesis • positive regulation of phosphatidylinositol 3-kinase signaling • platelet-derived growth factor receptor signaling pathway • lung alveolus development • positive regulation of cell division • actin cytoskeleton organization • positive regulation of MAPK cascade • skin development • phosphatidylinositol-mediated signaling • regulation of glomerular mesangial cell proliferation • regulation of peptidyl-tyrosine phosphorylation • positive regulation of GTPase activity • wound healing • phosphatidylinositol phosphorylation • positive regulation of cell proliferation • regulation of phosphatidylinositol 3-kinase signaling • negative regulation of platelet-derived growth factor receptor-beta signaling pathway • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5154	18590
Ensembl	ENSG00000197461	ENSMUSG00000025856
UniProt	P04085	P20033
RefSeq (mRNA)	NM_002607 NM_033023	NM_008808
RefSeq (protein)	NP_002598 NP_148983	NP_032834
Location (UCSC)	Chr 7: 0.5 – 0.52 Mb	Chr 5: 138.98 – 139 Mb
PubMed search

3MJK

5154

18590

ENSG00000197461

ENSMUSG00000025856

P04085

P20033

NM_002607
NM_033023

NM_008808

NP_002598
NP_148983

NP_032834

Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene.

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.

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