PCK1

PCK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KHB, 1KHE, 1KHF, 1KHG, 1M51, 1NHX, 2GMV
Identifiers
Aliases	PCK1, PEPCK-C, PEPEPCKC, phosphoenolpyruvate carboxykinase 1
External IDs	MGI: 97501 HomoloGene: 1944 GeneCards: PCK1
Gene location (Human) Chr. Chromosome 20 (human) Band No data available Start 57,561,080 bp End 57,568,112 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band No data available Start 173,153,048 bp End 173,159,273 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • manganese ion binding • GDP binding • phosphoenolpyruvate carboxykinase activity • GTP binding • metal ion binding • carboxylic acid binding • purine nucleotide binding • lyase activity • carboxy-lyase activity • magnesium ion binding • phosphoenolpyruvate carboxykinase (GTP) activity Cellular component • cytoplasm • cytosol • extracellular exosome Biological process • gluconeogenesis • glucose homeostasis • internal protein amino acid acetylation • lipid metabolic process • response to activity • positive regulation of transcription from RNA polymerase II promoter in response to acidic pH • oxaloacetate metabolic process • response to insulin • glycerol biosynthetic process from pyruvate • cellular response to potassium ion starvation • cellular response to retinoic acid • response to lipid • cellular response to hypoxia • cellular response to fructose stimulus • response to interleukin-6 • glucose metabolic process • aging • response to methionine • cellular response to interleukin-1 • cellular response to glucagon stimulus • cellular response to cAMP • cellular response to insulin stimulus • cellular response to tumor necrosis factor • response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5105	18534
Ensembl	ENSG00000124253	ENSMUSG00000027513
UniProt	P35558	Q9Z2V4
RefSeq (mRNA)	NM_002591	NM_011044
RefSeq (protein)	NP_002582	NP_035174
Location (UCSC)	Chr 20: 57.56 – 57.57 Mb	Chr 2: 173.15 – 173.16 Mb
PubMed search

1KHB, 1KHE, 1KHF, 1KHG, 1M51, 1NHX, 2GMV

5105

18534

ENSG00000124253

ENSMUSG00000027513

P35558

Q9Z2V4

NM_002591

NM_011044

NP_002582

NP_035174

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.

This enzyme is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized.

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