PAX9

PAX9
Identifiers
Aliases	PAX9, STHAG3, paired box 9
External IDs	MGI: 97493 HomoloGene: 31360 GeneCards: PAX9
Gene ontology Molecular function • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • protein binding • transcription factor activity, sequence-specific DNA binding Cellular component • nucleus Biological process • regulation of odontogenesis • multicellular organism development • cellular response to growth factor stimulus • endoderm development • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • face morphogenesis • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • odontogenesis • animal organ morphogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5083	18511
Ensembl	ENSG00000198807	ENSMUSG00000001497
UniProt	P55771	P47242
RefSeq (mRNA)	NM_006194	NM_011041
RefSeq (protein)	NP_006185	NP_035171.1 NP_035171
Location (UCSC)	Chr 14: 36.66 – 36.68 Mb	Chr 12: 56.69 – 56.71 Mb
PubMed search

5083

18511

ENSG00000198807

ENSMUSG00000001497

P55771

P47242

NM_006194

NM_011041

NP_006185

NP_035171.1
NP_035171

Paired box gene 9, also known as PAX9, is a protein which in humans is encoded by the PAX9 gene. It is also found in mammals.

This gene is a member of the paired box (PAX) family of transcription factors. During mouse embryogenesis Pax9 expression starts from embryonic day 8.5 and becomes more evident by E9.5; at this stage its expression is restricted to the pharyngeal endoderm. Later on, Pax9 is also expressed in the axial skeleton. Pax9 is required for craniofacial, tooth and limb development, and may more generally involve development of stratified squamous epithelia as well as various organs and skeletal elements. PAX9 plays a role in the absence of wisdom teeth in some human populations (possibly along with the less well studied AXIN2 and MSX1).

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Wikipedia