PARP1

PARP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UK0, 1UK1, 1WOK, 2COK, 2CR9, 2CS2, 2DMJ, 2JVN, 2L30, 2L31, 2RCW, 2RD6, 2RIQ, 3GJW, 3GN7, 3L3L, 3L3M, 3OD8, 3ODA, 3ODC, 3ODE, 4AV1, 4DQY, 4GV7, 4HHY, 4HHZ, 4L6S, 4OPX, 4OQA, 4OQB, 4PJT, 4UND, 4ZZZ, 5A00, 4R5W, 4R6E, 4UXB, 2N8A, 4XHU, 4RV6, 5HA9, 5DS3
Identifiers
Aliases	PARP1, ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1, poly(ADP-ribose) polymerase 1
External IDs	MGI: 1340806 HomoloGene: 1222 GeneCards: PARP1
Genetically Related Diseases
melanoma
Targeted by Drug
olaparib, rucaparib
Gene ontology Molecular function • transferase activity • DNA binding • R-SMAD binding • DNA ligase (ATP) activity • protein N-terminus binding • transferase activity, transferring glycosyl groups • NAD binding • zinc ion binding • transcription factor binding • histone deacetylase binding • metal ion binding • protein binding • identical protein binding • NAD+ ADP-ribosyltransferase activity • protein kinase binding • estrogen receptor binding • enzyme binding • SMAD binding • RNA binding Cellular component • nuclear envelope • membrane • transcription factor complex • nucleoplasm • protein complex • nucleolus • mitochondrion • nuclear chromosome, telomeric region • nucleus Biological process • positive regulation of transcription regulatory region DNA binding • lagging strand elongation • regulation of transcription, DNA-templated • protein ADP-ribosylation • mitochondrial DNA metabolic process • mitochondrial DNA repair • nucleotide-excision repair, DNA damage recognition • mitochondrion organization • signal transduction involved in regulation of gene expression • protein autoprocessing • regulation of cellular protein localization • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • macrophage differentiation • cellular response to DNA damage stimulus • positive regulation of cardiac muscle hypertrophy • global genome nucleotide-excision repair • double-strand break repair via homologous recombination • protein modification process • cellular response to insulin stimulus • negative regulation of telomere maintenance via telomere lengthening • protein poly-ADP-ribosylation • cellular response to oxidative stress • DNA ligation involved in DNA repair • nucleotide-excision repair, DNA incision • DNA repair • positive regulation of transcription from RNA polymerase II promoter • positive regulation of SMAD protein import into nucleus • DNA damage response, detection of DNA damage • nucleotide-excision repair, preincision complex assembly • regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • cellular response to zinc ion • regulation of SMAD protein complex assembly • cellular response to beta-amyloid • regulation of DNA methylation • positive regulation of mitochondrial depolarization • nucleotide-excision repair, DNA incision, 3'-to lesion • positive regulation of intracellular estrogen receptor signaling pathway • positive regulation of protein localization to nucleus • nucleotide-excision repair, DNA incision, 5'-to lesion • cellular response to transforming growth factor beta stimulus • double-strand break repair • transcription, DNA-templated • positive regulation of myofibroblast differentiation • nucleotide-excision repair, DNA duplex unwinding • positive regulation of neuron death • response to aldosterone • transforming growth factor beta receptor signaling pathway • nucleotide-excision repair, preincision complex stabilization • response to gamma radiation • regulation of catalytic activity • ATP generation from poly-ADP-D-ribose • negative regulation of ATP biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	142	11545
Ensembl	ENSG00000143799	ENSMUSG00000026496
UniProt	P09874	P11103
RefSeq (mRNA)	NM_001618	NM_007415
RefSeq (protein)	NP_001609 NP_001609.2	n/a
Location (UCSC)	Chr 1: 226.36 – 226.41 Mb	Chr 1: 180.57 – 180.6 Mb
PubMed search

1UK0, 1UK1, 1WOK, 2COK, 2CR9, 2CS2, 2DMJ, 2JVN, 2L30, 2L31, 2RCW, 2RD6, 2RIQ, 3GJW, 3GN7, 3L3L, 3L3M, 3OD8, 3ODA, 3ODC, 3ODE, 4AV1, 4DQY, 4GV7, 4HHY, 4HHZ, 4L6S, 4OPX, 4OQA, 4OQB, 4PJT, 4UND, 4ZZZ, 5A00, 4R5W, 4R6E, 4UXB, 2N8A, 4XHU, 4RV6, 5HA9, 5DS3

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