PAR-2

F2RL1
Identifiers
Aliases	F2RL1, GPR11, PAR2, Protease activated receptor 2, F2R like trypsin receptor 1
External IDs	MGI: 101910 HomoloGene: 21087 GeneCards: F2RL1
Gene location (Human) Chr. Chromosome 5 (human) Band 5q13.3 Start 76,818,933 bp End 76,835,315 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 D1|13 49.53 cM Start 95,511,732 bp End 95,525,227 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • thrombin-activated receptor activity • G-protein beta-subunit binding • protein binding • G-protein alpha-subunit binding • receptor binding • receptor activity Cellular component • integral component of membrane • Golgi apparatus • pseudopodium • membrane • plasma membrane • integral component of plasma membrane • early endosome Biological process • positive regulation of Rho protein signal transduction • establishment of endothelial barrier • chemokine (C-C motif) ligand 2 secretion • thrombin-activated receptor signaling pathway • neutrophil activation • positive regulation of phagocytosis, engulfment • positive regulation of toll-like receptor 3 signaling pathway • positive regulation of eosinophil degranulation • positive regulation of interleukin-6 secretion • positive regulation of neutrophil mediated killing of gram-negative bacterium • negative regulation of tumor necrosis factor-mediated signaling pathway • immune system process • positive regulation of cell migration • positive regulation of cytosolic calcium ion concentration • blood coagulation • positive regulation of JNK cascade • positive regulation of leukocyte chemotaxis • negative regulation of JNK cascade • leukocyte proliferation • regulation of JNK cascade • positive regulation of pseudopodium assembly • chemokine secretion • positive regulation of renin secretion into blood stream • interleukin-1 beta secretion • defense response to virus • positive regulation of chemotaxis • positive regulation of ERK1 and ERK2 cascade • positive regulation of cytokine secretion involved in immune response • positive regulation of toll-like receptor 4 signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of interleukin-8 secretion • positive regulation of toll-like receptor 2 signaling pathway • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of superoxide anion generation • interleukin-10 secretion • positive regulation of glomerular filtration • regulation of blood coagulation • inflammatory response • innate immune response • interferon-gamma secretion • negative regulation of chemokine secretion • mature conventional dendritic cell differentiation • negative regulation of toll-like receptor 3 signaling pathway • positive regulation of actin filament depolymerization • leukocyte migration • regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of transcription from RNA polymerase II promoter • positive regulation of positive chemotaxis • signal transduction • T cell activation involved in immune response • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • positive regulation of blood vessel diameter • G-protein coupled receptor signaling pathway • positive regulation of GTPase activity • cell-cell junction maintenance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2150	14063
Ensembl	ENSG00000164251	ENSMUSG00000021678
UniProt	P55085	P55086
RefSeq (mRNA)	NM_005242	NM_007974
RefSeq (protein)	NP_005233	NP_032000
Location (UCSC)	Chr 5: 76.82 – 76.84 Mb	Chr 5: 95.51 – 95.53 Mb
PubMed search

2150

14063

ENSG00000164251

ENSMUSG00000021678

P55085

P55086

NM_005242

NM_007974

NP_005233

NP_032000

Protease activated receptor 2 (PAR2) also known as coagulation factor II (thrombin) receptor-like 1 (F2RL1) or G-protein coupled receptor 11 (GPR11) is a protein that in humans is encoded by the F2RL1 gene. PAR2 modulates inflammatory responses, obesity, metabolism, and acts as a sensor for proteolytic enzymes generated during infection.

The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

PAR2 is a member of the large family of 7-transmembrane receptors that couple to guanosine-nucleotide-binding proteins. PAR2 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. Additionally, these receptors can be activated by exogenous proteases, such as house dust mite protein Der P9. These receptors can also be activated non-protealytically, by exogenous peptide sequences that mimic the final amino acids of the tethered ligand.

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