PAM (gene)

PAM
Identifiers
Aliases	PAM, PAL, PHM, Peptidylglycine alpha-amidating monooxygenase
External IDs	MGI: 97475 HomoloGene: 37369 GeneCards: PAM
Gene ontology Molecular function • metal ion binding • calcium ion binding • copper ion binding • lyase activity • protein kinase binding • monooxygenase activity • catalytic activity • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen • L-ascorbic acid binding • protein binding • zinc ion binding • peptidylglycine monooxygenase activity • peptidylamidoglycolate lyase activity Cellular component • extracellular exosome • extracellular region • integral component of membrane • trans-Golgi network • neuron projection • cell surface • neuronal cell body • perinuclear region of cytoplasm • plasma membrane • secretory granule membrane • secretory granule • perikaryon • membrane • extracellular space Biological process • response to hypoxia • limb development • ovulation cycle process • odontogenesis • regulation of protein secretion • response to estradiol • regulation of actin cytoskeleton organization • maternal process involved in female pregnancy • regulation of transcription from RNA polymerase II promoter • metabolic process • protein homooligomerization • response to copper ion • heart development • central nervous system development • toxin metabolic process • response to pH • response to glucocorticoid • protein amidation • protein metabolic process • oxidation-reduction process • long-chain fatty acid metabolic process • peptide metabolic process • response to drug • lactation • peptide amidation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5066	18484
Ensembl	ENSG00000145730	ENSMUSG00000026335
UniProt	P19021	P97467
RefSeq (mRNA)	NM_000919 NM_001177306 NM_138766 NM_138821 NM_138822 NM_001319943	NM_013626
RefSeq (protein)	NP_000910 NP_001170777 NP_001306872 NP_620121 NP_620176 NP_620177	NP_038654
Location (UCSC)	Chr 5: 102.75 – 103.03 Mb	Chr 1: 97.8 – 98.1 Mb
PubMed search

5066

18484

ENSG00000145730

ENSMUSG00000026335

P19021

P97467

NM_001319943

NM_013626

NP_620177

NP_038654

Peptidyl-glycine alpha-amidating monooxygenase is an enzyme that is required for the biosynthesis of many signaling peptides. This transformation is achieved by conversion of a prohormone to the corresponding amide (C(O)NH₂). This enzyme is the only known pathway for generating peptide amides, which renders the peptide more hydrophilic. In humans, PAM is encoded by the PAM gene.

This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences are not yet known.

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