P40 gene

IL12B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F42, 1F45, 3D85, 3D87, 3DUH, 3HMX, 3QWR, 4GRW, 4OE8, 4OG9
Identifiers
Aliases	IL12B, CLMF, CLMF2, IL-12B, IMD28, NKSF, NKSF2, IMD29, Interleukin 12 subunit beta, interleukin 12B
External IDs	MGI: 96540 HomoloGene: 1648 GeneCards: IL12B
Gene location (Human) Chr. Chromosome 5 (human) Band 5q33.3 Start 159,314,783 bp End 159,330,887 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B1.1|11 25.94 cM Start 44,400,063 bp End 44,414,033 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine activity • interleukin-23 receptor binding • protein homodimerization activity • interleukin-12 receptor binding • protein binding • identical protein binding • protein heterodimerization activity • interleukin-12 alpha subunit binding • cytokine receptor activity • growth factor activity • cytokine receptor binding Cellular component • cytoplasm • membrane • interleukin-12 complex • interleukin-23 complex • extracellular region • extracellular space • endoplasmic reticulum lumen • cytosol • late endosome lumen • cell surface Biological process • positive regulation of cell adhesion • negative regulation of interleukin-10 production • negative regulation of smooth muscle cell proliferation • positive regulation of inflammatory response • sexual reproduction • positive regulation of interleukin-12 production • negative regulation of growth of symbiont in host • positive regulation of smooth muscle cell apoptotic process • defense response to Gram-negative bacterium • positive regulation of interleukin-10 production • positive regulation of interferon-gamma biosynthetic process • positive regulation of T cell mediated cytotoxicity • natural killer cell activation • positive regulation of natural killer cell activation • positive regulation of interferon-gamma production • positive regulation of osteoclast differentiation • interferon-gamma biosynthetic process • positive regulation of T-helper 17 cell lineage commitment • response to organic substance • positive regulation of NK T cell activation • positive regulation of natural killer cell proliferation • natural killer cell activation involved in immune response • cell surface receptor signaling pathway • positive regulation of NK T cell proliferation • positive regulation of T-helper 17 type immune response • negative regulation of inflammatory response to antigenic stimulus • defense response to virus • positive regulation of tissue remodeling • positive regulation of T-helper 1 type immune response • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target • cell cycle arrest • positive regulation of granulocyte macrophage colony-stimulating factor production • positive regulation of T cell proliferation • positive regulation of memory T cell differentiation • cellular response to interferon-gamma • positive regulation of tumor necrosis factor production • T-helper 1 type immune response • regulation of cytokine biosynthetic process • nociception • response to UV-B • positive regulation of interleukin-17 production • cellular response to lipopolysaccharide • negative regulation of interleukin-17 production • T-helper cell differentiation • cell migration • positive regulation of lymphocyte proliferation • positive regulation of mononuclear cell proliferation • positive regulation of activated T cell proliferation • defense response to protozoan • positive regulation of defense response to virus by host • positive regulation of activation of Janus kinase activity • regulation of tyrosine phosphorylation of STAT protein • positive regulation of tyrosine phosphorylation of STAT protein • interleukin-12-mediated signaling pathway • cell proliferation • regulation of receptor activity • interferon-gamma production • T-helper 1 cell cytokine production • cytokine-mediated signaling pathway • interleukin-23-mediated signaling pathway • positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3593	16160
Ensembl	ENSG00000113302	ENSMUSG00000004296
UniProt	P29460	P43432
RefSeq (mRNA)	NM_002187	NM_008352 NM_001303244
RefSeq (protein)	NP_002178	NP_001290173
Location (UCSC)	Chr 5: 159.31 – 159.33 Mb	Chr 11: 44.4 – 44.41 Mb
PubMed search

1F42, 1F45, 3D85, 3D87, 3DUH, 3HMX, 3QWR, 4GRW, 4OE8, 4OG9

3593

16160

ENSG00000113302

ENSMUSG00000004296

P29460

P43432

NM_002187

NM_008352
NM_001303244

NP_002178

NP_001290173

Subunit beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12 subunit p40) is a protein that in humans is encoded by the IL12B gene. IL-12B is a common subunit of interleukin 12 and Interleukin 23.

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