P2RY6

P2RY6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B6R
Identifiers
Aliases	P2RY6, P2Y6, pyrimidinergic receptor P2Y6
External IDs	MGI: 2673874 HomoloGene: 14289 GeneCards: P2RY6
Gene ontology Molecular function • G-protein coupled purinergic nucleotide receptor activity • G-protein coupled receptor activity • protein binding • UDP-activated nucleotide receptor activity • signal transducer activity Cellular component • integral component of membrane • plasma membrane • basolateral plasma membrane • integral component of plasma membrane • apical plasma membrane • membrane Biological process • positive regulation of smooth muscle cell migration • phospholipase C-activating G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway • cellular response to organic cyclic compound • transepithelial chloride transport • signal transduction • G-protein coupled purinergic nucleotide receptor signaling pathway • cellular response to prostaglandin E stimulus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5031	233571
Ensembl	ENSG00000171631	ENSMUSG00000048779
UniProt	Q15077	Q9ERK9
RefSeq (mRNA)	NM_001277204 NM_001277205 NM_001277206 NM_001277207 NM_001277208 NM_004154 NM_176796 NM_176797 NM_176798	NM_183168
RefSeq (protein)	NP_001264133 NP_001264134 NP_001264135 NP_001264136 NP_001264137 NP_789766 NP_789767 NP_789768	NP_898991
Location (UCSC)	Chr 11: 73.26 – 73.3 Mb	Chr 7: 100.94 – 100.97 Mb
PubMed search

2B6R

5031

233571

ENSG00000171631

ENSMUSG00000048779

Q15077

Q9ERK9

NM_004154
NM_176796
NM_176797
NM_176798

NM_183168

NP_789766
NP_789767
NP_789768

NP_898991

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.

The product of this gene, P2Y₆, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.

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