P2RY1

P2RY1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XNV, 4XNW
Identifiers
Aliases	P2RY1, P2Y1, purinergic receptor P2Y1
External IDs	MGI: 105049 HomoloGene: 1926 GeneCards: P2RY1
Targeted by Drug
adenosine diphosphate, adenosine triphosphate, adenosine 3',5'-diphosphate, suramin
Gene ontology Molecular function • A1 adenosine receptor binding • G-protein coupled receptor activity • scaffold protein binding • ADP binding • G-protein coupled purinergic nucleotide receptor activity • signal transducer activity • ADP-activated adenosine receptor activity • protein binding • protein heterodimerization activity • ATP-activated adenosine receptor activity • ATP binding • receptor activity Cellular component • cell body • integral component of membrane • postsynaptic membrane • membrane • plasma membrane • integral component of plasma membrane • cell surface • dendrite • basolateral plasma membrane • apical plasma membrane • mitochondrion • postsynaptic density Biological process • hemostasis • cellular response to organic cyclic compound • G-protein coupled receptor signaling pathway • adenosine receptor signaling pathway • positive regulation of protein phosphorylation • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • eating behavior • positive regulation of cytosolic calcium ion concentration • response to mechanical stimulus • aging • regulation of receptor activity • negative regulation of norepinephrine secretion • signal transduction involved in regulation of gene expression • wound healing • G-protein coupled purinergic nucleotide receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • positive regulation of inositol trisphosphate biosynthetic process • negative regulation of binding • positive regulation of ion transport • positive regulation of ERK1 and ERK2 cascade • sensory perception of pain • response to growth factor • positive regulation of penile erection • protein localization to plasma membrane • positive regulation of hormone secretion • relaxation of muscle • positive regulation of transcription from RNA polymerase II promoter • glial cell migration • signal transduction • blood coagulation • platelet activation • regulation of blood vessel diameter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5028	18441
Ensembl	ENSG00000169860	ENSMUSG00000027765
UniProt	P47900	P49650
RefSeq (mRNA)	NM_002563	NM_001282016 NM_008772
RefSeq (protein)	NP_002554	NP_001268945.1 NP_032798.1 NP_001268945 NP_032798
Location (UCSC)	Chr 3: 152.83 – 152.84 Mb	Chr 3: 61 – 61.01 Mb
PubMed search

4XNV, 4XNW

5028

18441

ENSG00000169860

ENSMUSG00000027765

P47900

P49650

NM_002563

NM_001282016
NM_008772

NP_002554

NP_001268945.1
NP_032798.1
NP_001268945
NP_032798

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.

The product of this gene, P2Y₁ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.

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Wikipedia