P110δ

PIK3CD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5DXU
Identifiers
Aliases	PIK3CD, APDS, IMD14, P110DELTA, PI3K, p110D, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
External IDs	OMIM: 602839 MGI: 1098211 HomoloGene: 3686 GeneCards: PIK3CD
Gene ontology Molecular function • transferase activity • nucleotide binding • 1-phosphatidylinositol-3-kinase activity • 1-phosphatidylinositol-4-phosphate 3-kinase activity • protein binding • phosphatidylinositol 3-kinase activity • ATP binding • kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • phosphatidylinositol 3-kinase complex • cytosol • plasma membrane • mast cell granule • cytoplasm • intracellular Biological process • B cell receptor signaling pathway • cell differentiation • adaptive immune response • respiratory burst involved in defense response • B cell chemotaxis • immune system process • positive regulation of cell migration • T cell chemotaxis • cytokine production • natural killer cell activation • mast cell chemotaxis • neutrophil chemotaxis • chemotaxis • T cell differentiation • phosphatidylinositol phosphorylation • positive regulation of gene expression • natural killer cell chemotaxis • phosphatidylinositol biosynthetic process • mast cell differentiation • mast cell degranulation • innate immune response • inflammatory response • neutrophil extravasation • T cell receptor signaling pathway • T cell activation • phosphatidylinositol-mediated signaling • signal transduction • natural killer cell differentiation • B cell activation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process • axon guidance • phosphorylation • protein phosphorylation • phosphatidylinositol 3-kinase signaling • platelet activation • positive regulation of neutrophil apoptotic process • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5293	18707
Ensembl	ENSG00000171608	ENSMUSG00000039936
UniProt	O00329	O35904
RefSeq (mRNA)	NM_005026 NM_001350234 NM_001350235	NM_001029837 NM_001164049 NM_001164050 NM_001164051 NM_001164052 NM_008840
RefSeq (protein)	NP_005017 NP_001337163 NP_001337164 NP_005017.3	NP_001025008 NP_001157521 NP_001157522 NP_001157523 NP_001157524 NP_032866
Location (UCSC)	Chr 1: 9.65 – 9.73 Mb	Chr 4: 149.65 – 149.7 Mb
PubMed search

5DXU

5293

18707

ENSG00000171608

ENSMUSG00000039936

O00329

O35904

NM_005026
NM_001350234
NM_001350235

NM_008840

NP_005017
NP_001337163
NP_001337164
NP_005017.3

NP_032866

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase (PI3K) delta isoform or p110δ is an enzyme that in humans is encoded by the PIK3CD gene.

p110δ regulates immune function. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells). Genetic and pharmacological inactivation of p110δ has revealed that this enzyme is important for the function of T cells, B cell, mast cells and neutrophils. Hence, p110δ is a promising target for drugs that aim to prevent or treat inflammation, autoimmunity and transplant rejection.

...
Wikipedia