PIK3CB

PIK3CB
Identifiers
Aliases	PIK3CB, P110BETA, PI3K, PI3KBETA, PIK3C1, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
External IDs	MGI: 1922019 HomoloGene: 21250 GeneCards: PIK3CB
Gene ontology Molecular function • transferase activity • nucleotide binding • 1-phosphatidylinositol-4-phosphate 3-kinase activity • protein binding • phosphatidylinositol 3-kinase activity • insulin receptor substrate binding • ATP binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • kinase activity • 1-phosphatidylinositol-3-kinase activity Cellular component • cytosol • phosphatidylinositol 3-kinase complex • plasma membrane • nucleolus • nucleus • midbody • cytoplasm • intracellular Biological process • G-protein coupled receptor signaling pathway • embryonic cleavage • endocytosis • positive regulation of autophagy • Fc-gamma receptor signaling pathway involved in phagocytosis • transmembrane receptor protein tyrosine kinase signaling pathway • angiogenesis involved in wound healing • cellular calcium ion homeostasis • regulation of cell-matrix adhesion • platelet activation • autophagy • Fc-epsilon receptor signaling pathway • chemotaxis • phosphatidylinositol-3-phosphate biosynthetic process • phosphatidylinositol phosphorylation • positive regulation of gene expression • vascular endothelial growth factor receptor signaling pathway • cell adhesion • activation of MAPK activity • response to wounding • endothelial cell proliferation • phosphatidylinositol biosynthetic process • regulation of clathrin-dependent endocytosis • T cell receptor signaling pathway • platelet aggregation • cell migration • phosphatidylinositol-mediated signaling • leukocyte migration • signal transduction • homophilic cell adhesion via plasma membrane adhesion molecules • regulation of phosphatidylinositol 3-kinase signaling • axon guidance • phosphorylation • adaptive immune response • inflammatory response • phosphatidylinositol 3-kinase signaling • positive regulation of neutrophil apoptotic process • innate immune response • cell chemotaxis • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5291	74769
Ensembl	ENSG00000051382	ENSMUSG00000032462
UniProt	P42338	Q8BTI9
RefSeq (mRNA)	NM_001256045 NM_006219	NM_029094
RefSeq (protein)	NP_001242974 NP_006210	NP_083370
Location (UCSC)	Chr 3: 138.65 – 138.83 Mb	Chr 9: 99.04 – 99.14 Mb
PubMed search

5291

74769

ENSG00000051382

ENSMUSG00000032462

P42338

Q8BTI9

NM_001256045
NM_006219

NM_029094

NP_001242974
NP_006210

NP_083370

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene.

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM]

...
Wikipedia