Oxoeicosanoid receptor 1

OXER1

Identifiers

OXER1, GPCR, GPR170, TG1019, oxoeicosanoid (OXE) receptor 1, oxoeicosanoid receptor 1

External IDs

Targeted by Drug

Gene ontology
Molecular function	• 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding • 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding • 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding • G-protein coupled receptor activity • signal transducer activity
Cellular component	• integral component of membrane • plasma membrane • membrane
Biological process	• G-protein coupled receptor signaling pathway • regulation of cAMP biosynthetic process • signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


165140


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Ensembl


ENSG00000162881


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UniProt


Q8TDS5


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RefSeq (mRNA)


NM_148962


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RefSeq (protein)


NP_683765


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Location (UCSC)

Chr 2: 42.76 – 42.76 Mb

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PubMed search

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Oxoeicosanoid receptor 1 (OXER1) also known as G-protein coupled receptor 170 (GPR170) is a protein that in humans is encoded by the OXER1 gene located on human chromosome 2p21; it is the principle receptor for the 5-Hydroxyicosatetraenoic acid family of carboxy fatty acid metabolites derived from arachidonic acid. The receptor has also been termed hGPCR48, HGPCR48, and R527 but OXER1 is now its preferred designation. OXER1 is a G protein-coupled receptor (GPCR) that is structurally related to the hydroxy-carboxylic acid (HCA) family of G protein-coupled receptors whose three members are HCA1 (GPR81), HCA2 (Niacin receptor 1), and HCA3 (Niacin receptor 2); OXER1 has 30.3%, 30.7%, and 30.7% amino acid sequence identity with these GPCRs, respectively. It is also related (30.4% amino acid sequence identity) to the recently defined receptor, GPR31, for the hydroxyl-carboxy fatty acid 12-HETE.

Orthologs of OXER1 are found in various mammalian species including opossums and several species of fish; however, mice and rats lack a clear ortholog of OXER1. This represents an important hindrance to studies on the function of OXER1 since these two mammalian species are the most common and easiest models for investigating the in vivo functions of receptors in mammals and by extrapolation humans. Since mouse cells make and respond to members of the 5-HETE family of agonists, it is most likely that mice do have a receptor that substitutes for OXER1 by mediating their responses to this agonist family. Recently, A G protein-couple receptor of the hydroxy carboxilic acid subfamilty, Niacin receptor 1, has been proposed to mediate the responses of mouse tissues to 5-oxo-ETE.

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