Niacin receptor 1

HCAR2
Identifiers
Aliases	HCAR2, GPR109A, HCA2, HM74a, HM74b, NIACR1, PUMAG, Puma-g, Niacin receptor 1, hydroxycarboxylic acid receptor 2
External IDs	MGI: 1933383 HomoloGene: 4391 GeneCards: HCAR2
Gene ontology Molecular function • nicotinic acid receptor activity • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • cell junction • plasma membrane • membrane Biological process • apoptotic process • G-protein coupled receptor signaling pathway • negative regulation of lipid catabolic process • positive regulation of adiponectin secretion • signal transduction • positive regulation of neutrophil apoptotic process • neutrophil apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	338442	80885
Ensembl	ENSG00000182782	ENSMUSG00000045502
UniProt	Q8TDS4	Q9EP66
RefSeq (mRNA)	NM_177551	NM_030701
RefSeq (protein)	NP_808219	NP_109626.1 NP_109626
Location (UCSC)	Chr 12: 122.7 – 122.7 Mb	Chr 5: 123.86 – 123.87 Mb
PubMed search

338442

80885

ENSG00000182782

ENSMUSG00000045502

Q8TDS4

Q9EP66

NM_177551

NM_030701

NP_808219

NP_109626.1
NP_109626

Niacin receptor 1 (NIACR1), also known as hydroxycarboxylic acid receptor 2 (HCA2 or HCAR2) and GPR109A, is a protein which in humans is encoded by the HCAR2 gene.

NIACR1 is a high-affinity G_i/G_o-coupled G protein-coupled receptor (GPCR) for nicotinic acid (niacin), and is a member of the nicotinic acid receptor family of GPCRs. NIACR1 activation inhibits lipolytic and atherogenic activity (i.e., it inhibits the breakdown of fats and the development of atherosclerosis), induces vasodilation (i.e., the dilation of blood vessels), and is responsible for niacin-induced flushing.

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Wikipedia