Oncostatin M

OSM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EVS
Identifiers
Aliases	OSM, Osm, OncoM, oncostatin M
External IDs	MGI: 104749 HomoloGene: 10741 GeneCards: OSM
Gene ontology Molecular function • cytokine activity • oncostatin-M receptor binding • growth factor activity Cellular component • extracellular region • extracellular space • intracellular Biological process • peripheral nervous system development • oncostatin-M-mediated signaling pathway • positive regulation of apoptotic signaling pathway • response to heat • negative regulation of meiotic nuclear division • positive regulation of peptidyl-serine phosphorylation • multicellular organism development • behavioral response to pain • immune response • positive regulation of cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of acute inflammatory response • regulation of growth • cell proliferation • negative regulation of hormone secretion • positive regulation of cell division • positive regulation of MAPK cascade • negative regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of tyrosine phosphorylation of STAT protein • tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5008	18413
Ensembl	ENSG00000099985	ENSMUSG00000058755
UniProt	P13725	P53347
RefSeq (mRNA)	NM_020530 NM_001319108	NM_001013365
RefSeq (protein)	NP_001306037 NP_065391	NP_001013383.1 NP_001013383
Location (UCSC)	Chr 22: 30.26 – 30.27 Mb	Chr 11: 4.24 – 4.24 Mb
PubMed search

1EVS

5008

18413

ENSG00000099985

ENSMUSG00000058755

P13725

P53347

NM_020530
NM_001319108

NM_001013365

NP_001306037
NP_065391

NP_001013383.1
NP_001013383

Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene.

OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction.

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