Leukemia inhibitory factor

LIF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EMR, 1PVH, 2Q7N
Identifiers
Aliases	LIF, CDF, DIA, HILDA, MLPLI, leukemia inhibitory factor
External IDs	OMIM: 159540 MGI: 96787 HomoloGene: 1734 GeneCards: LIF
Gene ontology Molecular function • transcription factor activity, RNA polymerase II transcription factor recruiting • receptor binding • growth factor activity • cytokine activity • protein binding • leukemia inhibitory factor receptor binding Cellular component • extracellular region • extracellular space • cytosol Biological process • negative regulation of cell proliferation • stem cell differentiation • positive regulation of peptidyl-serine phosphorylation of STAT protein • positive regulation of MAPK cascade • positive regulation of peptidyl-serine phosphorylation • spongiotrophoblast differentiation • lung development • positive regulation of histone H3-K27 acetylation • positive regulation of tyrosine phosphorylation of Stat3 protein • multicellular organism development • lung lobe morphogenesis • muscle organ morphogenesis • maternal process involved in female pregnancy • negative regulation of hormone secretion • positive regulation of tyrosine phosphorylation of Stat1 protein • leukemia inhibitory factor signaling pathway • regulation of metanephric nephron tubule epithelial cell differentiation • regulation of cell differentiation • positive regulation of gene expression • stem cell population maintenance • positive regulation of peptidyl-tyrosine phosphorylation • regulation of RNA polymerase II regulatory region sequence-specific DNA binding • positive regulation of astrocyte differentiation • negative regulation of ERK1 and ERK2 cascade • neuron development • decidualization • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • lung alveolus development • positive regulation of macrophage differentiation • blood vessel remodeling • trophoblast giant cell differentiation • lung vasculature development • positive regulation of transcription from RNA polymerase II promoter • positive regulation of protein localization to nucleus • embryo implantation • tyrosine phosphorylation of Stat3 protein • negative regulation of meiotic nuclear division • immune response • positive regulation of cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3976	16878
Ensembl	ENSG00000128342	ENSMUSG00000034394
UniProt	P15018	P09056
RefSeq (mRNA)	NM_001257135 NM_002309	NM_001039537 NM_008501
RefSeq (protein)	NP_001244064 NP_002300	NP_001034626.1 NP_032527.1 NP_001034626 NP_032527
Location (UCSC)	Chr 22: 30.24 – 30.25 Mb	Chr 11: 4.26 – 4.27 Mb
PubMed search

1EMR, 1PVH, 2Q7N

3976

16878

ENSG00000128342

ENSMUSG00000034394

P15018

P09056

NM_001257135
NM_002309

NM_001039537
NM_008501

NP_001244064
NP_002300

NP_001034626.1
NP_032527.1
NP_001034626
NP_032527

Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate.

...
Wikipedia