Ohio State Route 40 (1923-1927)

U.S. Route 22
Route information
Length:	647.45 mi (1,041.97 km)
Existed:	1926 – present
Major junctions
West end:	US 27 / US 42 / US 52 / US 127 in Cincinnati, OH
	I‑70 near Zanesville, OH I‑77 near Cambridge, OH I‑79 in Collier Township, PA I-76 / I-376 / Penna Turnpike in Monroeville, PA I‑99 in Hollidaysburg, PA I‑81 / I‑83 near Harrisburg, PA I-78 in Union Township, PA I-476 / Penna Turnpike NE Extension near Allentown, PA I-78 from Alpha to Clinton, NJ G.S. Parkway in Union Township, NJ
East end:	I‑78 / US 1-9 in Newark, NJ
Location
States:	Ohio, West Virginia, Pennsylvania, New Jersey
Highway system
United States Numbered Highway System List Special Divided Replaced

U.S. Route 22 (US 22) is a west–east route and is one of the original United States highways of 1926, running from Cincinnati, Ohio, at US 27, US 42, US 127, and US 52 to Newark, New Jersey, at U.S. Route 1/9 in the Newark Airport Interchange. US 22 is named the "William Penn Highway" throughout most of Pennsylvania. In southwest Ohio, it overlaps with State Route 3 and is familiarly known as the 3C Highway, "22 and 3", and Montgomery Road.

A section of US 22 in Pennsylvania between New Alexandria at U.S. Route 119 and Harrisburg at Interstate 81 has been designated a part of Corridor M of the Appalachian Development Highway System.

US 22 has its westernmost end-point in downtown Cincinnati—however, its eastbound and westbound end-points are not at the same intersection. Officially, US 22 Eastbound begins on Central Avenue (US 27 northbound/US 52 westbound/US 127 northbound) at 5th Street, then proceeds north, turning east onto 7th Street. Meanwhile, US 22 Westbound follows 9th Street and officially ends at Central Avenue (signage designating the end occurs much sooner, approaching Elm Street, U.S. Route 42 Northbound).

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Wikipedia