Odoardo Farnese (12 August 1666 – 6 September 1693) was the eldest son of Duke Ranuccio II Farnese, Duke of Parma and Piacenza. Odoardo was the Hereditary Prince of Parma from his birth till his death. He was the father of the famously domineering Elisabeth Farnese.

Odoardo was born on 21 August 1666 at the Ducal Palace of Colorno in Colorno outside the city of Parma. His father, Duke Ranuccio II Farnese, was the Duke of Parma and of Piacenza. His mother, Isabella d´Este, was the daughter of Francesco I d'Este, Duke of Modena and of Maria Caterina Farnese. Thus, Odoardo's parents were first cousins to each other. He was the third child of his parents, and had two older sisters, Margherita Maria Farnese, future wife of Francesco II d'Este, Duke of Modena, and Teresa Farnese, who never married but became a benedictine nun and abbess of the Sant Alessandro monastery in Parma.

Odoardo's mother, Isabella d´Este, died some twelve days after giving birth to him. She had been his father's second wife. Odoardo's father had been previously married to Princess Margaret Yolande of Savoy, first cousin of Louis XIV, but that marriage had not produced any surviving children (only two stillborn infants). After the death of Odoardo's mother, his father took a third wife, marrying the younger sister of his late spouse; thus, Odoardo's step-mother was his own aunt. This was Maria d'Este, and she bore the duke a further nine children, including two surviving sons. Among them was Francesco Farnese, twelve years younger than Odoardo, who would marry Odoardo's widow Dorothea Sophie, be a devoted and beloved step-father to Odoardo's daughter Elisabeth Farnese, and inherit the Dukedom of Parma upon the death of their father.

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