OSTbeta

SLC51B
Identifiers
Aliases	SLC51B, OSTB, OSTBETA, OSTbeta, solute carrier family 51 beta subunit
External IDs	MGI: 3582052 HomoloGene: 18721 GeneCards: SLC51B
Gene location (Human) Chr. Chromosome 15 (human) Band 15q22.31 Start 65,045,370 bp End 65,053,396 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 C Start 65,412,714 bp End 65,422,955 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transporter activity • protein heterodimerization activity Cellular component • integral component of membrane • plasma membrane • membrane • protein complex Biological process • positive regulation of protein glycosylation • regulation of protein stability • positive regulation of protein exit from endoplasmic reticulum • bile acid and bile salt transport • positive regulation of protein targeting to membrane • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	123264	330962
Ensembl	ENSG00000186198	ENSMUSG00000053862
UniProt	Q86UW2	Q80WK2
RefSeq (mRNA)	NM_178859	NM_178933
RefSeq (protein)	NP_849190	NP_849264
Location (UCSC)	Chr 15: 65.05 – 65.05 Mb	Chr 15: 65.41 – 65.42 Mb
PubMed search

123264

330962

ENSG00000186198

ENSMUSG00000053862

Q86UW2

Q80WK2

NM_178859

NM_178933

NP_849190

NP_849264

Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.

OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes. The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake. The heterodimer furthermore is essential for intestinal bile acid transport.

OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.

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