OSTalpha

SLC51A
Identifiers
Aliases	SLC51A, OSTA, OSTalpha, solute carrier family 51 alpha subunit
External IDs	MGI: 2146634 HomoloGene: 44941 GeneCards: SLC51A
Gene location (Human) Chr. Chromosome 3 (human) Band No data available Start 196,211,487 bp End 196,243,178 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band No data available Start 32,475,522 bp End 32,487,879 bp
Gene ontology Molecular function • protein homodimerization activity • protein heterodimerization activity • transporter activity Cellular component • protein complex • integral component of membrane • plasma membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane Biological process • bile acid and bile salt transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	200931	106407
Ensembl	ENSG00000163959	ENSMUSG00000035699
UniProt	Q86UW1	Q8R000
RefSeq (mRNA)	NM_152672	NM_145932
RefSeq (protein)	NP_689885	NP_666044
Location (UCSC)	Chr 3: 196.21 – 196.24 Mb	Chr 3: 32.48 – 32.49 Mb
PubMed search

200931

106407

ENSG00000163959

ENSMUSG00000035699

Q86UW1

Q8R000

NM_152672

NM_145932

NP_689885

NP_666044

Organic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the OSTA gene.

OST-alpha together with OST-beta is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes. The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake. The heterodimer furthermore is essential for intestinal bile acid transport.

OST-alpha and OST-alpha have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.

...
Wikipedia