ORC5L

ORC5
Identifiers
Aliases	ORC5, ORC5L, ORC5P, ORC5T, PPP1R117, origin recognition complex subunit 5
External IDs	MGI: 1347044 HomoloGene: 37636 GeneCards: ORC5
Gene ontology Molecular function • nucleotide binding • DNA replication origin binding • protein binding • ATP binding Cellular component • nuclear origin of replication recognition complex • origin recognition complex • nuclear chromosome, telomeric region • nucleus • nucleoplasm • cytosol Biological process • G1/S transition of mitotic cell cycle • DNA replication • DNA replication initiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5001	26429
Ensembl	ENSG00000164815	ENSMUSG00000029012
UniProt	O43913	Q9WUV0
RefSeq (mRNA)	NM_001197292 NM_002553 NM_181747	NM_011959
RefSeq (protein)	NP_002544 NP_859531	NP_036089
Location (UCSC)	Chr 7: 104.13 – 104.21 Mb	Chr 5: 22.49 – 22.55 Mb
PubMed search

5001

26429

ENSG00000164815

ENSMUSG00000029012

O43913

Q9WUV0

NM_001197292
NM_002553
NM_181747

NM_011959

NP_002544
NP_859531

NP_036089

Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and 4L. Alternatively spliced transcript variants encoding distinct isoforms have been described.

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