OPN5

OPN5
Identifiers
Aliases	OPN5, GPR136, GRP136, PGR12, TMEM13, opsin 5
External IDs	MGI: 2662912 HomoloGene: 72341 GeneCards: OPN5
Gene ontology Molecular function • 11-cis retinal binding • G-protein coupled receptor activity • photoreceptor activity • signal transducer activity • G-protein coupled photoreceptor activity Cellular component • integral component of membrane • membrane • photoreceptor outer segment Biological process • protein-chromophore linkage • signal transduction • visual perception • response to stimulus • G-protein coupled receptor signaling pathway • phototransduction • detection of visible light Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221391	353344
Ensembl	ENSG00000124818	ENSMUSG00000043972
UniProt	Q6U736	Q6VZZ7
RefSeq (mRNA)	NM_001030051 NM_181744	NM_181753
RefSeq (protein)	NP_859528	NP_861418.2 NP_861418
Location (UCSC)	Chr 6: 47.78 – 47.83 Mb	Chr 17: 42.56 – 42.61 Mb
PubMed search

221391

353344

ENSG00000124818

ENSMUSG00000043972

Q6U736

Q6VZZ7

NM_001030051
NM_181744

NM_181753

NP_859528

NP_861418.2
NP_861418

Neuropsin is a protein that in humans is encoded by the OPN5 gene. It is a photoreceptor protein sensitive to ultraviolet (UV) light. The OPN5 gene was discovered in mouse and human genomes and its mRNA expression was also found in neural tissues. Neuropsin is bistable at 0 °C and activates a UV-sensitive, heterotrimeric G protein Gi-mediated pathway in mammalian and avian tissues.

Opsins are members of the G protein-coupled receptor superfamily. Human neuropsin is expressed in the eye, brain, testes, and spinal cord. Neuropsin belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Neuropsin has different isoforms created by alternative splicing.

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Wikipedia