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OPN5

OPN5
Identifiers
Aliases OPN5, GPR136, GRP136, PGR12, TMEM13, opsin 5
External IDs MGI: 2662912 HomoloGene: 72341 GeneCards: OPN5
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001030051
NM_181744

NM_181753

RefSeq (protein)

NP_859528

NP_861418.2
NP_861418

Location (UCSC) Chr 6: 47.78 – 47.83 Mb Chr 17: 42.56 – 42.61 Mb
PubMed search

NM_001030051
NM_181744

NM_181753

NP_859528

NP_861418.2
NP_861418

Neuropsin is a protein that in humans is encoded by the OPN5 gene. It is a photoreceptor protein sensitive to ultraviolet (UV) light. The OPN5 gene was discovered in mouse and human genomes and its mRNA expression was also found in neural tissues. Neuropsin is bistable at 0 °C and activates a UV-sensitive, heterotrimeric G protein Gi-mediated pathway in mammalian and avian tissues.

Opsins are members of the G protein-coupled receptor superfamily. Human neuropsin is expressed in the eye, brain, testes, and spinal cord. Neuropsin belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Neuropsin has different isoforms created by alternative splicing.


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Wikipedia

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