OPN5 | |||||||||||||||||
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Identifiers | |||||||||||||||||
Aliases | OPN5, GPR136, GRP136, PGR12, TMEM13, opsin 5 | ||||||||||||||||
External IDs | MGI: 2662912 HomoloGene: 72341 GeneCards: OPN5 | ||||||||||||||||
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Orthologs | |||||||||||||||||
Species | Human | Mouse | |||||||||||||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | Chr 6: 47.78 – 47.83 Mb | Chr 17: 42.56 – 42.61 Mb | |||||||||||||||
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Neuropsin is a protein that in humans is encoded by the OPN5 gene. It is a photoreceptor protein sensitive to ultraviolet (UV) light. The OPN5 gene was discovered in mouse and human genomes and its mRNA expression was also found in neural tissues. Neuropsin is bistable at 0 °C and activates a UV-sensitive, heterotrimeric G protein Gi-mediated pathway in mammalian and avian tissues.
Opsins are members of the G protein-coupled receptor superfamily. Human neuropsin is expressed in the eye, brain, testes, and spinal cord. Neuropsin belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Neuropsin has different isoforms created by alternative splicing.