OAS1

OAS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4IG8
Identifiers
Aliases	OAS1, IFI-4, OIAS, OIASI, E18/E16, 2'-5'-oligoadenylate synthetase 1
External IDs	MGI: 2180860 HomoloGene: 1903 GeneCards: OAS1
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.13 Start 112,906,777 bp End 112,933,222 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 F|5 60.65 cM Start 120,896,256 bp End 120,907,521 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • nucleotidyltransferase activity • metal ion binding • protein binding • RNA binding • double-stranded RNA binding • ATP binding • 2'-5'-oligoadenylate synthetase activity Cellular component • cytoplasm • intracellular membrane-bounded organelle • extracellular region • endoplasmic reticulum • mitochondrion • cell nucleus • cytosol Biological process • purine nucleotide biosynthetic process • regulation of ribonuclease activity • glucose homeostasis • interferon-gamma-mediated signaling pathway • immune system process • response to virus • negative regulation of viral genome replication • defense response to virus • type I interferon signaling pathway • protein oligomerization • immune response • glucose metabolic process • cellular response to interferon-alpha • innate immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4938	246730
Ensembl	ENSG00000089127	ENSMUSG00000052776
UniProt	P00973	P11928
RefSeq (mRNA)	NM_001032409 NM_002534 NM_016816 NM_001320151	NM_145211
RefSeq (protein)	NP_001027581 NP_001307080 NP_002525 NP_058132	NP_660212
Location (UCSC)	Chr 12: 112.91 – 112.93 Mb	Chr 5: 120.9 – 120.91 Mb
PubMed search

4IG8

4938

246730

ENSG00000089127

ENSMUSG00000052776

P00973

P11928

NM_001032409
NM_002534
NM_016816
NM_001320151

NM_145211

NP_001027581
NP_001307080
NP_002525
NP_058132

NP_660212

2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene.

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in both viral and endogenous RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

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