RNase L

RNASEL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WDY, 4G8K, 4G8L, 4OAU, 4OAV
Identifiers
Aliases	RNASEL, PRCA1, RNS4, ribonuclease L
External IDs	OMIM: 180435 MGI: 1098272 HomoloGene: 8040 GeneCards: RNASEL
Gene ontology Molecular function • nucleotide binding • protein kinase activity • rRNA binding • metal ion binding • endoribonuclease activity • ribonuclease activity • protein binding • RNA binding • nuclease activity • ribonucleoprotein complex binding • endonuclease activity • hydrolase activity • ATP binding Cellular component • cytoplasm • cytosol • nuclear matrix • mitochondrial matrix • mitochondrion Biological process • regulation of mRNA stability • nucleic acid phosphodiester bond hydrolysis • mRNA processing • positive regulation of glucose import in response to insulin stimulus • protein phosphorylation • negative regulation of viral genome replication • RNA phosphodiester bond hydrolysis • defense response to virus • type I interferon signaling pathway • rRNA processing • fat cell differentiation • positive regulation of transcription from RNA polymerase II promoter • RNA phosphodiester bond hydrolysis, endonucleolytic • regulation of type I interferon-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6041	24014
Ensembl	ENSG00000135828	ENSMUSG00000066800
UniProt	Q05823	Q05921
RefSeq (mRNA)	NM_021133	NM_011882
RefSeq (protein)	NP_066956	NP_036012.1 NP_036012
Location (UCSC)	Chr 1: 182.57 – 182.59 Mb	Chr 1: 153.75 – 153.76 Mb
PubMed search

1WDY, 4G8K, 4G8L, 4OAU, 4OAV

6041

24014

ENSG00000135828

ENSMUSG00000066800

Q05823

Q05921

NM_021133

NM_011882

NP_066956

NP_036012.1
NP_036012

Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease — is an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral). RNase L is an enzyme that in humans is encoded by the RNASEL gene.

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Wikipedia