Coordinates: 38°57′15″N 33°57′33″E / 38.954295°N 33.959229°E Nyssa (Ancient Greek: Νύσσα) was a small town in Cappadocia. The Antonine Itinerary places it on the road from Ancyra to Caesarea, between Parnassos and Asiana, 24 Roman miles from Parnassus and 32 from Asiana. Ptolemy's Geography places it at 68°20' 38°40 (in his degrees) in the Prefecture of Murimene (Ancient Greek: Στρατηγίας Μουριμηνῆς). The Synecdemus and the Notitiae Episcopatuum indicate that Nyssa was in the Roman province of Cappadocia Prima.
The site of Nyssa has been identified as near the modern town of Harmandalı, Ortaköy district, Aksaray province, in south-central Turkey. The archaeological site consists of two tells, named Büyükkale (big castle) and Küçükkale (little castle), located 2 km to the north of Harmandalı. Another proposed location associates it with the modern city of Nevşehir, but modern scholarship has cast serious doubt on this.