Nucleocytoplasmic large DNA viruses
| Megavirales | |
|---|---|
| Virus classification | |
| Group: | Group I (dsDNA) |
| Families | |
|
Ascoviridae |
|
Ascoviridae
Asfarviridae
Iridoviridae
Marseilleviridae
Megaviridae
Mimiviridae
Pandoraviridae
Phycodnaviridae
Pithoviridae
Poxviridae
The nucleocytoplasmic large DNA viruses or NCLDV, proposed as a new order Megavirales (i.e., the giant viruses), are a number of families of large DNA viruses:
Two unassigned genera, Dinodnavirus and Faustovirus, also belong to this clade. Another virus – Pacmanvirus – has been described. This virus appears to be related to Faustovirus, Kaumoebavirus and the Asfarviridae. Also Mollivirus and Ectocarpus siliculosus virus (ESV-1) have been placed into this clade.
All have both common and unique features of genomic DNA and virion structure. It remains uncertain whether the similarities of different families of this group have a common viral ancestor, although the latter theory is controversial and under heavy scrutiny.
There are 47 NCLDV core genes currently recognised. These include the four key proteins involved in DNA replication and repair. These include the enzymes DNA polymerase family B, the topoisomerase II A, the FLAP endonuclease and the processing factor proliferating cell nuclear antigen. Other proteins include the DNA dependent RNA polymerase II and transcription factor II B.
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