5-lipoxygenase-activating protein

ALOX5AP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q7R, 2Q7M
Identifiers
Aliases	ALOX5AP, FLAP, arachidonate 5-lipoxygenase activating protein
External IDs	OMIM: 603700 MGI: 107505 HomoloGene: 1231 GeneCards: ALOX5AP
Gene location (Human) Chr. Chromosome 13 (human) Band 13q12.3 Start 30,713,478 bp End 30,764,426 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G3 Start 149,264,767 bp End 149,288,153 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • glutathione transferase activity • protein N-terminus binding • leukotriene-C4 synthase activity • glutathione peroxidase activity • protein binding • arachidonic acid binding • enzyme activator activity Cellular component • integral component of membrane • nuclear membrane • endoplasmic reticulum membrane • membrane • nuclear envelope • endoplasmic reticulum • cell nucleus Biological process • cellular response to calcium ion • leukotriene metabolic process • positive regulation of catalytic activity • protein homotrimerization • lipoxygenase pathway • leukotriene biosynthetic process • lipoxin metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	241	11690
Ensembl	ENSG00000132965	ENSMUSG00000060063
UniProt	P20292	P30355
RefSeq (mRNA)	NM_001204406 NM_001629	NM_009663 NM_001308462
RefSeq (protein)	NP_001191335 NP_001620	NP_001295391 NP_033793
Location (UCSC)	Chr 13: 30.71 – 30.76 Mb	Chr 5: 149.26 – 149.29 Mb
PubMed search

2Q7R, 2Q7M

241

11690

ENSG00000132965

ENSMUSG00000060063

P20292

P30355

NM_001204406
NM_001629

NM_009663
NM_001308462

NP_001191335
NP_001620

NP_001295391
NP_033793

Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the ALOX5AP gene.

FLAP is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes, 5-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid, and specialized pro-resolving mediators of the lipoxin and resolvin classes. It is an integral protein within the nuclear membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. How FLAP activates 5-lipooxygenase is not completely understood, but there is a physical interaction between the two. FLAP structure consist of 4 transmembrane alpha helices, but they are found in 3’s( trimer) forming a barrel. The barrel is about 60 A high and 36 A wide.

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