Proliferating cell nuclear antigen

PCNA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D2G, 1AXC, 1U76, 1U7B, 1UL1, 1VYJ, 1VYM, 1W60, 2ZVK, 2ZVL, 2ZVM, 3P87, 3TBL, 3VKX, 3WGW, 4RJF, 3JA9, 4ZTD, 5IY4, 5E0U, 5E0T, 5E0V
Identifiers
Aliases	PCNA, ATLD2, proliferating cell nuclear antigen
External IDs	OMIM: 176740 MGI: 97503 HomoloGene: 1945 GeneCards: PCNA
Gene ontology Molecular function • MutLalpha complex binding • identical protein binding • enzyme binding • receptor tyrosine kinase binding • DNA binding • DNA polymerase binding • damaged DNA binding • dinucleotide insertion or deletion binding • protein binding • chromatin binding • histone acetyltransferase binding • estrogen receptor binding • purine-specific mismatch base pair DNA N-glycosylase activity • DNA polymerase processivity factor activity Cellular component • nucleus • replisome • nucleoplasm • nuclear chromosome, telomeric region • extracellular exosome • DNA replication factor C complex • centrosome • PCNA complex • nuclear replication fork • PCNA-p21 complex • replication fork • nuclear body Biological process • replication fork processing • translesion synthesis • DNA replication • nucleotide-excision repair, DNA gap filling • protein sumoylation • regulation of DNA replication • transcription-coupled nucleotide-excision repair • DNA damage response, detection of DNA damage • positive regulation of deoxyribonuclease activity • nucleotide-excision repair, DNA incision • error-free translesion synthesis • positive regulation of DNA repair • regulation of transcription involved in G1/S transition of mitotic cell cycle • positive regulation of DNA replication • response to lipid • heart development • mismatch repair • cellular response to DNA damage stimulus • mitotic telomere maintenance via semi-conservative replication • epithelial cell differentiation • response to cadmium ion • cell proliferation • telomere maintenance • error-prone translesion synthesis • cellular response to UV • estrous cycle • cellular response to hydrogen peroxide • response to dexamethasone • nucleotide-excision repair, DNA incision, 5'-to lesion • liver regeneration • response to estradiol • response to oxidative stress • DNA repair • response to L-glutamate • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • DNA ligation • leading strand elongation • protein ubiquitination • telomere maintenance via semi-conservative replication Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5111	18538
Ensembl	ENSG00000132646	ENSMUSG00000027342
UniProt	P12004	P17918
RefSeq (mRNA)	NM_182649 NM_002592	NM_011045
RefSeq (protein)	NP_002583 NP_872590	NP_035175
Location (UCSC)	Chr 20: 5.11 – 5.13 Mb	Chr 2: 132.25 – 132.25 Mb
PubMed search

4D2G, 1AXC, 1U76, 1U7B, 1UL1, 1VYJ, 1VYM, 1W60, 2ZVK, 2ZVL, 2ZVM, 3P87, 3TBL, 3VKX, 3WGW, 4RJF, 3JA9, 4ZTD, 5IY4, 5E0U, 5E0T, 5E0V

5111

18538

ENSG00000132646

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Wikipedia